| Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m. | |
| | |
MedLine Citation:
|
PMID: 20367484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a randomized, placebo-controlled, double-blind study, we tested a 4-week program in normobaric hypoxia that is commercially offered for the prevention of acute mountain sickness (AMS). Twenty-two male and 18 female healthy subjects [mean age 33 +/- 7 (SD) years] exercised 70 min, 3 x /week for 3 weeks on a bicycle ergometer at workloads of 60% VO2max either in normoxia (normoxia group, NG) or in normobaric hypoxia (hypoxia group, HG), corresponding to altitudes of 2500, 3000, and 3500 m during weeks 1, 2, and 3, respectively. Four passive exposures of 90 min in normoxia (NG) or hypoxia corresponding to 4500 m (HG) followed in week 4. Five days after the last session, subjects ascended within 24 h from sea level to 4559 m (one overnight stay at 3611 m) and stayed there for 24 h. AMS was defined as LL (Lake Louise score) > or =5 and AMS-C > or =0.70. The AMS incidence (70% in NG vs. 60% in HG, p = 0.74), LL scores (7.1 +/- 4.3 vs. 5.9 +/- 3.4, p = 0.34), and AMS-C scores (1.50 +/- 1.22 vs. 0.93 +/- 0.81, p = 0.25) at the study endpoint were not significantly different between the groups. However, the incidence of AMS at 3611 m (6% vs. 47%, p = 0.01) and the functional LL score at 4559 m were lower in HG. SpO2 at 3611 m, heart rate during ascents, and arterial blood gases at 4559 m were not different between groups. We conclude that the tested program does not reduce the incidence of AMS within a rapid ascent to 4559 m, but our data show that it prevents AMS at lower altitudes. Whether such a program would prevent AMS at higher altitudes, but with slower ascent, remains to be tested. |
| | |
Authors:
|
Kai Schommer; Neele Wiesegart; Elmar Menold; Ute Haas; Katrin Lahr; Hermann Buhl; Peter Bärtsch; Christoph Dehnert |
Related Documents
:
|
15831744 - Ocean science. coral clues to rapid sea-level change. 16764524 - Work capacity of permanent residents of high altitude. 4084174 - Analyses of maximum cardiopulmonary performance during exposure to acute hypoxia at sim... 20358704 - Biochemical markers of possible immunodepression in military training in harsh environm... 16934174 - Effects of gender and prior swim exercise on glucose uptake in isolated skeletal muscle... 7900074 - Long-term stability studies on the who irp for thromboplastin (human plain bct/253). |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: High altitude medicine & biology Volume: 11 ISSN: 1557-8682 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-04-06 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 19-25 Citation Subset: IM; S |
Affiliation:
|
Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany. kai.schommer@med.uni-heidelberg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acclimatization* Adult Altitude Sickness / epidemiology, prevention & control* Anoxia* Blood Gas Analysis Double-Blind Method Female Heart Rate Hematocrit Hemoglobins / analysis Humans Lactic Acid / blood Male Oximetry Physical Education and Training / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) ge...
Next Document: A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is...