Document Detail


Training in the fasted state facilitates re-activation of eEF2 activity during recovery from endurance exercise.
MedLine Citation:
PMID:  21132439     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nutrition is an important co-factor in exercise-induced training adaptations in muscle. We compared the effect of 6 weeks endurance training (3 days/week, 1-2 h at 75% VO(2peak)) in either the fasted state (F; n = 10) or in the high carbohydrate state (CHO, n = 10), on Ca(2+)-dependent intramyocellular signalling in young male volunteers. Subjects in CHO received a carbohydrate-rich breakfast before each training session, as well as ingested carbohydrates during exercise. Before (pretest) and after (posttest) the training period, subjects performed a 2 h constant-load exercise bout (~70% of pretest VO(2peak)) while ingesting carbohydrates (1 g/kg h(-1)). A muscle biopsy was taken from m. vastus lateralis immediately before and after the test, and after 4 h of recovery. Compared with pretest, in the posttest basal eukaryotic elongation factor 2 (eEF2) phosphorylation was elevated in CHO (P < 0.05), but not in F. In the pretest, exercise increased the degree of eEF2 phosphorylation about twofold (P < 0.05), and values returned to baseline within the 4 h recovery period in each group. However, in the posttest dephosphorylation of eEF2 was negated after recovery in CHO, but not in F. Independent of the dietary condition training enhanced the basal phosphorylation status of Phospholamban at Thr(17), 5'-AMP-activated protein kinase α (AMPKα), and Acetyl CoA carboxylase β (ACCβ), and abolished the exercise-induced increase of AMPKα and ACCβ (P < 0.05). In conclusion, training in the fasted state, compared with identical training with ample carbohydrate intake, facilitates post-exercise dephosphorylation of eEF2. This may contribute to rapid re-activation of muscle protein translation following endurance exercise.
Authors:
K Van Proeyen; K De Bock; P Hespel
Related Documents :
16601539 - Risk factors for lack of recent exercise in adults with self-reported, professionally d...
10381509 - Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement ...
21522069 - Postexercise carbohydrate-protein supplementation improves subsequent exercise performa...
2324999 - Type a behavior and exercise: a follow-up study of coronary patients.
21257979 - Impact of aerobic training on cardiovascular reactivity to and recovery from challenge.
1660219 - Effects of transcatheter hepatic arterial embolization on coagulation and fibrinolysis ...
16242459 - Hypoxia-reoxygenation, st. thomas cardioplegic solution, and nicorandil on endothelium-...
9622579 - Mechanics and energetics of human locomotion on sand.
18001359 - Brachial arterial dynamics during staged lower extremity exercise: utility and comparis...
Publication Detail:
Type:  Journal Article     Date:  2010-12-04
Journal Detail:
Title:  European journal of applied physiology     Volume:  111     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1297-305     Citation Subset:  IM    
Affiliation:
Department of Biomedical Kinesiology, Research Centre for Exercise and Health, FaBeR-K.U. Leuven, Tervuursevest 101, 3001, Leuven, Heverlee, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Short term effects of various water immersions on recovery from exhaustive intermittent exercise.
Next Document:  Passive repetitive loading of the lumbar tissues influences force output and EMG during maximal effo...