Document Detail


Training does not protect against exhaustive exercise-induced lactate transport capacity alterations.
MedLine Citation:
PMID:  10827007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of endurance training on lactate transport capacity remain controversial. This study examined whether endurance training 1) alters lactate transport capacity, 2) can protect against exhaustive exercise-induced lactate transport alteration, and 3) can modify heart and oxidative muscle monocarboxylate transporter 1 (MCT1) content. Forty male Wistar rats were divided into control (C), trained (T), exhaustively exercised (E), and trained and exercised (TE) groups. Rats in the T and TE groups ran on a treadmill (1 h/day, 5 days/wk at 25 m/min, 10% incline) for 5 wk; C and E were familiarized with the exercise task for 5 min/day. Before being killed, E and TE rats underwent exhaustive exercise (25 m/min, 10% grade), which lasted 80 and 204 min, respectively (P < 0.05). Although lactate transport measurements (zero-trans) did not differ between groups C and T, both E and TE groups presented an apparent loss of protein saturation properties. In the trained groups, MCT1 content increased in soleus (+28% for T and +26% for TE; P < 0.05) and heart muscle (+36% for T and +33% for TE; P < 0.05). Moreover, despite the metabolic adaptations typically observed after endurance training, we also noted increased lipid peroxidation byproducts after exhaustive exercise. We concluded that 1) endurance training does not alter lactate transport capacity, 2) exhaustive exercise-induced lactate transport alteration is not prevented by training despite increased MCT1 content, and 3) exercise-induced oxidative stress may enhance the passive diffusion responsible for the apparent loss of saturation properties, possibly masking lactate transport regulation.
Authors:
N Eydoux; G Py; K Lambert; H Dubouchaud; C Préfaut; J Mercier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  278     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-17     Completed Date:  2000-07-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E1045-52     Citation Subset:  IM; S    
Affiliation:
Laboratoire de Physiologie des Interactions, Service Central de Physiologie Clinique, Hôpital Arnaud de Villeneuve, 34295 Montpellier, France. physio34@aol.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Body Weight
Carrier Proteins / metabolism
Glycogen / metabolism
Lactic Acid / blood,  metabolism*
Lipid Peroxidation
Male
Malondialdehyde / metabolism
Monocarboxylic Acid Transporters
Muscle, Skeletal / metabolism
Myocardium / metabolism
Physical Conditioning, Animal
Physical Endurance / physiology*
Rats
Rats, Wistar
Sarcolemma / metabolism
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Monocarboxylic Acid Transporters; 50-21-5/Lactic Acid; 542-78-9/Malondialdehyde; 9005-79-2/Glycogen

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