| Training does not protect against exhaustive exercise-induced lactate transport capacity alterations. | |
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MedLine Citation:
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PMID: 10827007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of endurance training on lactate transport capacity remain controversial. This study examined whether endurance training 1) alters lactate transport capacity, 2) can protect against exhaustive exercise-induced lactate transport alteration, and 3) can modify heart and oxidative muscle monocarboxylate transporter 1 (MCT1) content. Forty male Wistar rats were divided into control (C), trained (T), exhaustively exercised (E), and trained and exercised (TE) groups. Rats in the T and TE groups ran on a treadmill (1 h/day, 5 days/wk at 25 m/min, 10% incline) for 5 wk; C and E were familiarized with the exercise task for 5 min/day. Before being killed, E and TE rats underwent exhaustive exercise (25 m/min, 10% grade), which lasted 80 and 204 min, respectively (P < 0.05). Although lactate transport measurements (zero-trans) did not differ between groups C and T, both E and TE groups presented an apparent loss of protein saturation properties. In the trained groups, MCT1 content increased in soleus (+28% for T and +26% for TE; P < 0.05) and heart muscle (+36% for T and +33% for TE; P < 0.05). Moreover, despite the metabolic adaptations typically observed after endurance training, we also noted increased lipid peroxidation byproducts after exhaustive exercise. We concluded that 1) endurance training does not alter lactate transport capacity, 2) exhaustive exercise-induced lactate transport alteration is not prevented by training despite increased MCT1 content, and 3) exercise-induced oxidative stress may enhance the passive diffusion responsible for the apparent loss of saturation properties, possibly masking lactate transport regulation. |
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Authors:
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N Eydoux; G Py; K Lambert; H Dubouchaud; C Préfaut; J Mercier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 278 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-17 Completed Date: 2000-07-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E1045-52 Citation Subset: IM; S |
Affiliation:
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Laboratoire de Physiologie des Interactions, Service Central de Physiologie Clinique, Hôpital Arnaud de Villeneuve, 34295 Montpellier, France. physio34@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Body Weight Carrier Proteins / metabolism Glycogen / metabolism Lactic Acid / blood, metabolism* Lipid Peroxidation Male Malondialdehyde / metabolism Monocarboxylic Acid Transporters Muscle, Skeletal / metabolism Myocardium / metabolism Physical Conditioning, Animal Physical Endurance / physiology* Rats Rats, Wistar Sarcolemma / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Monocarboxylic Acid Transporters; 50-21-5/Lactic Acid; 542-78-9/Malondialdehyde; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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