| Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF). | |
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MedLine Citation:
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PMID: 20553806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain derived neurotrophic factor (BDNF) is postulated to be an important mediator of exercise-induced neuroprotection. We tested the hypothesis that resistance exercise elevates circulating BDNF. Twenty healthy untrained college-aged males underwent a 5-week traditional or eccentric-enhanced progressive resistance training intervention. Blood was acquired at rest and 1, 30, and 60min following a standardized resistance exercise testing bout performed at baseline and at the completion of the intervention. Serum BDNF responses did not differ between the two groups at any time point during baseline or post-intervention testing; thus, all values were combined into a single cohort for further analysis. Resting BDNF was not altered by the exercise training intervention [23,304+/-1835pg/ml (baseline) vs. 19,433+/-1992pg/ml (post-intervention)]. Following the baseline resistance exercise bout, serum BDNF increased 32% (p<0.05) and was gradually reduced to 41% below resting levels at 60min into recovery (p<0.01). During post-intervention testing, serum BDNF increased 77% in response to the standardized resistance exercise bout (p<0.01) and returned to resting values within 30min. Ultimately, the change in serum BDNF from rest to immediately post-exercise was 98% greater at post-intervention than at baseline (p<0.05). Our study is the first to demonstrate that resistance exercise induces a robust, yet transient, elevation of circulating BDNF and that progressive resistance training augments this response; perhaps demonstrating one mechanism through which exercise influences brain health. |
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Authors:
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Joshua F Yarrow; Lesley J White; Sean C McCoy; Stephen E Borst |
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Publication Detail:
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Type: Journal Article Date: 2010-05-27 |
Journal Detail:
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Title: Neuroscience letters Volume: 479 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ireland Ltd. |
Affiliation:
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VA Medical Center GRECC, Gainesville, FL 32608, United States. jfyarrow@ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain-Derived Neurotrophic Factor / blood* Humans Male Physical Endurance / physiology* Resistance Training* |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor |
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