| Training affects muscle phospholipid fatty acid composition in humans. | |
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MedLine Citation:
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PMID: 11160068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Training improves insulin sensitivity, which in turn may affect performance by modulation of fuel availability. Insulin action, in turn, has been linked to specific patterns of muscle structural lipids in skeletal muscle. This study investigated whether regular exercise training exerts an effect on the muscle membrane phospholipid fatty acid composition in humans. Seven male subjects performed endurance training of the knee extensors of one leg for 4 wk. The other leg served as a control. Before, after 4 days, and after 4 wk, muscle biopsies were obtained from the vastus lateralis. After 4 wk, the phospholipid fatty acid contents of oleic acid 18:1(n-9) and docosahexaenoic acid 22:6(n-3) were significantly higher in the trained (10.9 +/- 0.5% and 3.2 +/- 0.4% of total fatty acids, respectively) than the untrained leg (8.8 +/- 0.5% and 2.6 +/- 0.4%, P < 0.05). The ratio between n-6 and n-3 fatty acids was significantly lower in the trained (11.1 +/- 0.9) than the untrained leg (13.1 +/- 1.2, P < 0.05). In contrast, training did not affect muscle triacylglycerol fatty acid composition. Citrate synthase activity was increased by 17% in the trained compared with the untrained leg (P < 0.05). In this model, diet plays a minimal role, as the influence of dietary intake is similar on both legs. Regular exercise training per se influences the phospholipid fatty acid composition of muscle membranes but has no effect on the composition of fatty acids stored in triacylglycerols within the muscle. |
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Authors:
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J W Helge; B J Wu; M Willer; J R Daugaard; L H Storlien; B Kiens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 90 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 670-7 Citation Subset: IM |
Affiliation:
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Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK-2100 DK-Copenhagen, Denmark. Jhelge@cmrc.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Docosahexaenoic Acids / analysis Energy Intake Exercise Test Fatty Acids / analysis* Fatty Acids, Unsaturated / analysis Humans Male Muscle, Skeletal / enzymology, metabolism* Oleic Acids / analysis Phospholipids / chemistry* Physical Endurance* Triglycerides / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Oleic Acids; 0/Phospholipids; 0/Triglycerides; 143-25-9/11-octadecenoic acid; 25167-62-8/Docosahexaenoic Acids |
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