| Trafficking of vesicular neurotransmitter transporters. | |
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MedLine Citation:
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PMID: 18507811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vesicular neurotransmitter transporters are required for the storage of all classical and amino acid neurotransmitters in secretory vesicles. Transporter expression can influence neurotransmitter storage and release, and trafficking targets the transporters to different types of secretory vesicles. Vesicular transporters traffic to synaptic vesicles (SVs) as well as large dense core vesicles and are recycled to SVs at the nerve terminal. Some of the intrinsic signals for these trafficking events have been defined and include a dileucine motif present in multiple transporter subtypes, an acidic cluster in the neural isoform of the vesicular monoamine transporter (VMAT) 2 and a polyproline motif in the vesicular glutamate transporter (VGLUT) 1. The sorting of VMAT2 and the vesicular acetylcholine transporter to secretory vesicles is regulated by phosphorylation. In addition, VGLUT1 uses alternative endocytic pathways for recycling back to SVs following exocytosis. Regulation of these sorting events has the potential to influence synaptic transmission and behavior. |
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Authors:
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Hao Fei; Anna Grygoruk; Elizabeth S Brooks; Audrey Chen; David E Krantz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-05-26 |
Journal Detail:
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Title: Traffic (Copenhagen, Denmark) Volume: 9 ISSN: 1600-0854 ISO Abbreviation: Traffic Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-08 Completed Date: 2008-12-08 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100939340 Medline TA: Traffic Country: Denmark |
Other Details:
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Languages: eng Pagination: 1425-36 Citation Subset: IM |
Affiliation:
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Departments of Psychiatry and Neurobiology, Gonda Goldschmied Neuroscience and Genetics Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1761, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endocytosis / physiology Humans Neurotransmitter Agents / metabolism* Neurotransmitter Transport Proteins / metabolism* Protein Transport Secretory Vesicles / metabolism*, physiology Synaptic Transmission / physiology |
| Grant Support | |
ID/Acronym/Agency:
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ES015747/ES/NIEHS NIH HHS; GM07185/GM/NIGMS NIH HHS; MH076900/MH/NIMH NIH HHS; P01 ES016732-010002/ES/NIEHS NIH HHS; R01 ES015747-03S2/ES/NIEHS NIH HHS; R01 MH076900-03/MH/NIMH NIH HHS; R01 NS051453-01/NS/NINDS NIH HHS; T32/MH019384/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 0/Neurotransmitter Transport Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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