| Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes. | |
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MedLine Citation:
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PMID: 19794399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolic brain imaging is widely used to evaluate brain function and disease, and quantitative assays require local retention of compounds used to register changes in cellular activity. As labeled metabolites of [1- and 6-(14)C]glucose are rapidly released in large quantities during brain activation, this study evaluated release of metabolites and proteins through perivascular fluid flow, a pathway that carries solutes from brain to peripheral lymphatic drainage sites. Assays with [3,4-(14)C]glucose ruled out local oxidation of glucose-derived lactate as a major contributor of label loss. Brief infusion of [1-(14)C]glucose and D-[(14)C]lactate into the inferior colliculus of conscious rats during acoustic stimulation labeled the meninges, consistent with perivascular clearance of [(14)C]metabolites from interstitial fluid. Microinfusion of Evans blue albumin and amyloid-beta(1-40) (Abeta) caused perivascular labeling in the inferior colliculus, labeled the surrounding meninges, and Abeta-labeled-specific blood vessels in the caudate and olfactory bulb and was deposited in cervical lymph nodes. Efflux of extracellular glucose, lactate, and Abeta into perivascular fluid pathways is a normal route for clearance of material from the inferior colliculus that contributes to underestimates of brain energetics. Convergence of 'watershed' drainage to common pathways may facilitate perivascular amyloid plaque formation and pathway obstruction in Alzheimer's disease. |
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Authors:
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Kelly K Ball; Nancy F Cruz; Robert E Mrak; Gerald A Dienel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-09-30 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-04 Completed Date: 2010-02-03 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 162-76 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism Amyloid beta-Peptides / metabolism* Animals Brain Chemistry / physiology Chromatography, High Pressure Liquid Coloring Agents Evans Blue Glucose / metabolism* Inferior Colliculi / metabolism* Lactic Acid / metabolism* Lymphatic System / metabolism Male Meninges / metabolism Microdialysis Microinjections Models, Neurological Rats Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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NS047546/NS/NINDS NIH HHS; NS36728/NS/NINDS NIH HHS; P30 NS047546-05/NS/NINDS NIH HHS; R01 NS036728-07/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Coloring Agents; 314-13-6/Evans Blue; 50-21-5/Lactic Acid; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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