Document Detail

Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study.
MedLine Citation:
PMID:  21067713     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels.
OBJECTIVES: To evaluate the impact of maternal exposure to traffic-related air pollution during pregnancy on preterm birth and term birth weight using a spatio-temporal exposure model.
METHODS: We estimated maternal residential exposure to nitrogen dioxide (NO(2)), particulate matter (PM(2.5)) and soot during pregnancy (entire pregnancy, 1st trimester, and last month) for 3853 singleton births within the Dutch PIAMA prospective birth cohort study by means of temporally adjusted land-use regression models. Associations between air pollution concentrations and preterm birth and term birth weight were analyzed by means of logistic and linear regression models with and without adjustment for maternal physical, lifestyle, and socio-demographic characteristics.
RESULTS: We found positive, statistically non-significant associations between exposure to soot during entire pregnancy and during the last month of pregnancy and preterm birth [adj. OR (95% CI) per interquartile range increase in exposure 1.08 (0.88-1.34) and 1.09 (0.93-1.27), respectively]. There was no indication of an adverse effect of air pollution exposure on term birth weight.
CONCLUSIONS: In this study, maternal exposure to traffic-related air pollution during pregnancy was not associated with term birth weight. There was a tendency towards an increased risk of preterm birth with increasing air pollution exposure, but statistical power was low.
Ulrike Gehring; Alet H Wijga; Paul Fischer; Johan C de Jongste; Marjan Kerkhof; Gerard H Koppelman; Henriette A Smit; Bert Brunekreef
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Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  Environmental research     Volume:  111     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands.
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