Document Detail

Traffic-related air pollution and childhood respiratory symptoms, function and allergies.
MedLine Citation:
PMID:  18379426     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization. METHODS: The spatial distribution of nitrogen oxides from traffic (traffic-NOx) and inhalable particulate matter from traffic (traffic-PM10) in the study area was assessed with emission databases and dispersion modeling. Estimated levels were used to assign first-year exposure levels for children in a prospective birth cohort (n = 4089), by linking to geocoded home addresses. Parents in 4 Swedish municipalities provided questionnaire data on symptoms and exposures when the children were 2 months and 1, 2, and 4-year-old. At 4 years, 73% of the children underwent clinical examination including peak expiratory flow and specific IgE measurements. RESULTS: Exposure to air pollution from traffic during the first year of life was associated with an excess risk of persistent wheezing (odds ratio [OR] for 44 microg/m3 [5th-95th percentile] difference in traffic-NOx = 1.60; 95% confidence interval [CI] = 1.09-2.36). Similar results were found for sensitization (measured as specific IgE) to inhalant allergens, especially pollen (OR for traffic-NOx = 1.67; 95% CI = 1.10-2.53), at the age of 4 years. Traffic-related air pollution exposure during the first year of life was also associated with lower lung function at 4 years of age. Results were similar using traffic-NOx and traffic-PM10 as indicators. CONCLUSIONS: Exposure to moderate levels of locally emitted air pollution from traffic early in life appears to influence the development of airway disease and sensitization in preschool children.
Emma Nordling; Niklas Berglind; Erik Melén; Gunnel Emenius; Jenny Hallberg; Fredrik Nyberg; Göran Pershagen; Magnus Svartengren; Magnus Wickman; Tom Bellander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  19     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-8     Citation Subset:  IM    
Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden.
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MeSH Terms
Child, Preschool
Environmental Exposure / adverse effects*,  analysis
Hypersensitivity / epidemiology*,  etiology,  physiopathology
Immunoglobulin E / analysis
Nitrogen Oxides / adverse effects*,  analysis*
Particulate Matter / adverse effects*,  analysis
Prospective Studies
Regression Analysis
Respiratory Function Tests
Respiratory Tract Diseases / epidemiology*,  etiology,  physiopathology
Risk Factors
Socioeconomic Factors
Sweden / epidemiology
Vehicle Emissions / analysis*
Reg. No./Substance:
0/Nitrogen Oxides; 0/Particulate Matter; 0/Vehicle Emissions; 37341-29-0/Immunoglobulin E

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