| Traffic noise exposure increases gastric acid secretion in rat. | |
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MedLine Citation:
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PMID: 21132997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noise is considered as one of the most severe sources of environmental and work place constraints. Noise effects on immune function, hormonal levels, cardiovascular and respiratory systems are well known. The aim of the study is to evaluate the effects of traffic noise on basal and stimulated gastric acid secretion. 48 healthy rats were divided into five traffic noise exposures (1, 7, 14, 21, 28 days) and a control groups. Pentagastrin was used i.p. for stimulation of gastric acid secretion. The gastric contents were collected by the wash-out technique and then titrated. Histological studies were performed on gastric epithelial layer. In the 1, 7, 14 and 21 days traffic noise exposure, basal and pentagastrin-stimulated gastric acid secretion increased compared to the control group (P<0.001), but a significant decrease was seen in hyperacidity in 28th days, in the both basal and stimulated states (P<0.05). Histological study showed that mucosal layer thickness of stomach increased, while the number of oxyntic glands and cell nuclei decreased. It seems that 1,7,14 and 21 days traffic noise increase gastric acid secretion, while 28 days traffic noise can induce adaptation. |
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Authors:
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Azam Moslehi; Fatemeh Nabavizadeh-Rafsanjani; Mansoor Keshavarz; Nematollah Rouhbakhsh; Masoud Sotudeh; Ehsan Salimi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Iranica Volume: 48 ISSN: 0044-6025 ISO Abbreviation: Acta Med Iran Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-12-07 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 14540050R Medline TA: Acta Med Iran Country: Iran |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Analysis of Variance Animals Gastric Acid / secretion* Gastric Mucosa / pathology, secretion Male Noise, Transportation* Pentagastrin / pharmacology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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