| Traffic exposure in a population with high prevalence type 2 diabetes--do medications influence concentrations of C-reactive protein? | |
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MedLine Citation:
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PMID: 21292365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 2 Diabetes (T2D) and particulate air pollution are associated with inflammatory dysregulation. We assessed the modifying effects of diabetes medications on the association of C-reactive protein (CRP), a marker of inflammation, and traffic exposure in adults with T2D (n = 379). CRP concentrations were significantly positively associated with residence ≤100 m of a roadway, >100 m and ≤200 m of a roadway and increased traffic density for individuals using insulin. For individuals using oral hypoglycemic medications (OHAs), CRP was significantly negatively associated with residence >100 m - ≤200 m of a roadway and multiple roadway exposure in an interaction model. Among people with diabetes, individuals on insulin appear to be most vulnerable to the effects of traffic exposure. Disease severity among insulin users may promote the pro-inflammatory response to traffic exposure, though diabetes medications may also modify the response. Possible anti-inflammatory effects of OHAs with traffic exposure merit further evaluation. |
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Authors:
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Christine L Rioux; Katherine L Tucker; Doug Brugge; David M Gute; Mkaya Mwamburi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-02 |
Journal Detail:
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Title: Environmental pollution (Barking, Essex : 1987) Volume: 159 ISSN: 1873-6424 ISO Abbreviation: Environ. Pollut. Publication Date: 2011 Aug-Sep |
Date Detail:
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Created Date: 2011-06-13 Completed Date: 2011-09-30 Revised Date: 2012-01-27 |
Medline Journal Info:
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Nlm Unique ID: 8804476 Medline TA: Environ Pollut Country: England |
Other Details:
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Languages: eng Pagination: 2051-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Public Health and Community Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA. christine.rioux@tufts.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Air Pollutants / analysis, toxicity* Air Pollution / statistics & numerical data Biological Markers / metabolism C-Reactive Protein / metabolism* Cross-Sectional Studies Diabetes Mellitus, Type 2 / epidemiology*, immunology, metabolism Environmental Exposure / analysis, statistics & numerical data* Female Humans Hypoglycemic Agents / metabolism* Insulin / metabolism Longitudinal Studies Male Middle Aged Prevalence Vehicle Emissions / analysis, toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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P01-AG023394/AG/NIA NIH HHS; P50HL105185-01/HL/NHLBI NIH HHS; R01 ES015462-01A1/ES/NIEHS NIH HHS; R01 ES015462-02/ES/NIEHS NIH HHS; R01 ES015462-02/ES/NIEHS NIH HHS; R01 ES015462-03/ES/NIEHS NIH HHS; R01 ES015462-03S1/ES/NIEHS NIH HHS; R01 ES015462-04/ES/NIEHS NIH HHS; R01 ES015462-05/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Biological Markers; 0/Hypoglycemic Agents; 0/Insulin; 0/Vehicle Emissions; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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