Document Detail

Traffic-related air pollution and the right ventricle. The multi-ethnic study of atherosclerosis.
MedLine Citation:
PMID:  24593877     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Right heart failure is a cause of morbidity and mortality in common and rare heart and lung diseases. Exposure to traffic-related air pollution is linked to left ventricular hypertrophy, heart failure, and death. Relationships between traffic-related air pollution and right ventricular (RV) structure and function have not been studied.
OBJECTIVES: To characterize the relationship between traffic-related air pollutants and RV structure and function.
METHODS: We included men and women with magnetic resonance imaging assessment of RV structure and function and estimated residential outdoor nitrogen dioxide (NO2) concentrations from the Multi-ethnic Study of Atherosclerosis, a study of individuals free of clinical cardiovascular disease at baseline. Multivariable linear regression estimated associations between NO2 exposure (averaged over the year prior to magnetic resonance imaging) and measures of RV structure and function after adjusting for demographics, anthropometrics, smoking status, diabetes mellitus, and hypertension. Adjustment for corresponding left ventricular parameters, traffic-related noise, markers of inflammation, and lung disease were considered in separate models. Secondary analyses considered oxides of nitrogen (NOx) as the exposure.
MEASUREMENTS AND MAIN RESULTS: The study sample included 3,896 participants. In fully adjusted models, higher NO2 was associated with greater RV mass and larger RV end-diastolic volume with or without further adjustment for corresponding left ventricular parameters, traffic-related noise, inflammatory markers, or lung disease (all P < 0.05). There was no association between NO2 and RV ejection fraction. Relationships between NOx and RV morphology were similar.
CONCLUSIONS: Higher levels of NO2 exposure were associated with greater RV mass and larger RV end-diastolic volume.
Peter J Leary; Joel D Kaufman; R Graham Barr; David A Bluemke; Cynthia L Curl; Catherine L Hough; Joao A Lima; Adam A Szpiro; Victor C Van Hee; Steven M Kawut
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  189     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-05-05     Completed Date:  2014-06-30     Revised Date:  2014-08-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-100     Citation Subset:  AIM; IM    
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MeSH Terms
African Americans
Air Pollutants / adverse effects*
Asian Americans
Atherosclerosis / ethnology,  etiology,  pathology*
Environmental Exposure / adverse effects
European Continental Ancestry Group
Heart Ventricles / drug effects,  pathology*
Hispanic Americans
Linear Models
Magnetic Resonance Imaging
Middle Aged
Nitrogen Dioxide / adverse effects*
Prospective Studies
Residence Characteristics
Time Factors
United States / epidemiology
Vehicle Emissions*
Ventricular Function, Right* / physiology
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Vehicle Emissions; S7G510RUBH/Nitrogen Dioxide
Comment In:
Am J Respir Crit Care Med. 2014 May 1;189(9):1018-9   [PMID:  24787063 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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