Document Detail

Traffic-Related Air Pollution and Lung Function In Children At 8 Years Of Age - A Birth Cohort Study.
MedLine Citation:
PMID:  23103735     Owner:  NLM     Status:  Publisher    
ABSTRACT RATIONALE: Long-term exposure to air pollution has been related to lung function decrements in children, but the role of timing of exposure remains unknown. OBJECTIVES: To assess the role of long-term exposure to air pollution on lung function in school-age children. METHODS: Over 1900 children in the Swedish birth cohort BAMSE were followed with repeated questionnaires, dynamic spirometry and IgE measurements until 8 years of age. Outdoor concentrations of particulate matter with an aerodynamic diameter <10 μm (PM10) from road traffic were estimated for residential, daycare and school addresses from birth and onwards using dispersion modelling. The relationship between time-weighted average exposure during different time windows and forced expiratory volumes at 8 years was analyzed by linear regression, adjusting for potential confounding factors, including short-term exposure to air pollution. RESULTS: A 5th to 95th percentile difference in time-weighted average PM10 exposure during the first year of life was associated with a reduced forced expiratory volume in one second (FEV1) of -59.3 mL, 95% confidence interval (CI): -113.0 to -5.6 at 8 years of age. The negative association was particularly pronounced in children concomitantly sensitized to common inhalant and/or food allergens (-136.9 mL, 95% CI: -224.1 to -49.7). Exposure after the first year of life appeared to have less impact on lung function at 8 years. CONCLUSIONS: Our results indicate that exposure to traffic-related air pollution during infancy affects lung function in children up to 8 years of age and particularly in those sensitized to common inhalant and/or food allergens. Word count: 249.
Erica S Schultz; Olena Gruzieva; Tom Bellander; Matteo Bottai; Jenny Hallberg; Inger Kull; Magnus Svartengren; Erik Melén; Göran Pershagen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-26
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Insitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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