| Traffic-Related Air Pollution and Lung Function In Children At 8 Years Of Age - A Birth Cohort Study. | |
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MedLine Citation:
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PMID: 23103735 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT RATIONALE: Long-term exposure to air pollution has been related to lung function decrements in children, but the role of timing of exposure remains unknown. OBJECTIVES: To assess the role of long-term exposure to air pollution on lung function in school-age children. METHODS: Over 1900 children in the Swedish birth cohort BAMSE were followed with repeated questionnaires, dynamic spirometry and IgE measurements until 8 years of age. Outdoor concentrations of particulate matter with an aerodynamic diameter <10 μm (PM10) from road traffic were estimated for residential, daycare and school addresses from birth and onwards using dispersion modelling. The relationship between time-weighted average exposure during different time windows and forced expiratory volumes at 8 years was analyzed by linear regression, adjusting for potential confounding factors, including short-term exposure to air pollution. RESULTS: A 5th to 95th percentile difference in time-weighted average PM10 exposure during the first year of life was associated with a reduced forced expiratory volume in one second (FEV1) of -59.3 mL, 95% confidence interval (CI): -113.0 to -5.6 at 8 years of age. The negative association was particularly pronounced in children concomitantly sensitized to common inhalant and/or food allergens (-136.9 mL, 95% CI: -224.1 to -49.7). Exposure after the first year of life appeared to have less impact on lung function at 8 years. CONCLUSIONS: Our results indicate that exposure to traffic-related air pollution during infancy affects lung function in children up to 8 years of age and particularly in those sensitized to common inhalant and/or food allergens. Word count: 249. |
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Authors:
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Erica S Schultz; Olena Gruzieva; Tom Bellander; Matteo Bottai; Jenny Hallberg; Inger Kull; Magnus Svartengren; Erik Melén; Göran Pershagen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-26 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: - ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Insitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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