Document Detail

Traffic-related air pollution and lung function in children at 8 years of age: a birth cohort study.
MedLine Citation:
PMID:  23103735     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Long-term exposure to air pollution has been related to lung function decrements in children, but the role of timing of exposure remains unknown.
OBJECTIVES: To assess the role of long-term exposure to air pollution on lung function in school-age children.
METHODS: More than 1,900 children in the Swedish birth cohort BAMSE were followed with repeated questionnaires, dynamic spirometry, and IgE measurements until 8 years of age. Outdoor concentrations of particulate matter with an aerodynamic diameter less than 10 μm (PM(10)) from road traffic were estimated for residential, day care, and school addresses from birth and onward using dispersion modeling. The relationship between time-weighted average exposure during different time windows and FEV at 8 years was analyzed by linear regression, adjusting for potential confounding factors, including short-term exposure to air pollution.
MEASUREMENTS AND MAIN RESULTS: A 5th to 95th percentile difference in time-weighted average particulate matter less than 10 μm in aerodynamic diameter exposure during the first year of life was associated with a reduced FEV(1) of -59.3 ml (95% confidence interval, -113 to -5.6) at 8 years of age. The negative association was particularly pronounced in children concomitantly sensitized to common inhalant or food allergens (-136.9 ml; 95% confidence interval, -224.1 to -49.7). Exposure after the first year of life seemed to have less impact on lung function at 8 years.
CONCLUSIONS: Our results indicate that exposure to traffic-related air pollution during infancy affects lung function in children up to 8 years of age and particularly in those sensitized to common inhalant or food allergens.
Erica S Schultz; Olena Gruzieva; Tom Bellander; Matteo Bottai; Jenny Hallberg; Inger Kull; Magnus Svartengren; Erik Melén; Göran Pershagen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-26
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  186     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-18     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1286-91     Citation Subset:  AIM; IM    
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MeSH Terms
Air Pollution / adverse effects*
Environmental Monitoring
Forced Expiratory Volume / drug effects
Hypersensitivity, Immediate / complications*
Immunoglobulin E / analysis
Linear Models
Lung / drug effects*,  physiopathology
Particulate Matter / adverse effects*
Prospective Studies
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Particulate Matter; 0/Vehicle Emissions; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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