| Traditional thoughts on the pathophysiology of irritable bowel syndrome. | |
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MedLine Citation:
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PMID: 21333899 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The pathogenesis of symptoms in irritable bowel syndrome (IBS) is multifactorial and varies from patient to patient. Disturbances of motor function in the small intestine and colon and smooth-muscle dysfunction in other gut and extraintestinal regions are prominent. Abnormalities of sensory function in visceral and somatic structures are detected in most patients with IBS, which may relate to peripheral sensitization or altered central nervous system processing of afferent information. Contributions from psychosocial disturbances are observed in patients from tertiary centers and primary practice. Proof of causation of symptom genesis for most of these factors is limited. |
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Authors:
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William L Hasler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology clinics of North America Volume: 40 ISSN: 1558-1942 ISO Abbreviation: Gastroenterol. Clin. North Am. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706257 Medline TA: Gastroenterol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 21-43 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, Ann Arbor, MI 48109, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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