| Traditional medicine Taeeumjowitangkagambang exerts antiobesity and hypolipidemic effects via antioxidant enzyme enhancement. | |
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MedLine Citation:
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PMID: 21031632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taeeumjowitangkagambang (ETJKB) is a traditional Korean medicine that has been clinically used for obesity with little mechanistic understanding. The present study investigated antiobesity and hypolipidemic effects of ETJKB in high fat diet fed rats as well as a 3T3-L1 pre-adipocyte differentiation model. ETJKB significantly inhibited the lipidogenesis in 3T3-L1 adipocytes in a concentration-dependent manner as well as reduced the cellular adipokine leptin level. Daily oral gavage of ETJKB to rats fed a high fat diet significantly attenuated body weight gain and abdominal and epididymal fat weights. ETJKB treatment also reduced the levels of total cholesterol, low density lipoprotein (LDL) and triglyceride as well as increased high density lipoprotein (HDL) in serum compared with the untreated control. Similarly, the ETJKB treatment decreased the levels of total lipid, triglyceride and cholesterol in liver tissue in high fat diet fed rats. Interestingly, ETJKB significantly increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase in liver tissue, while decreasing the hydroxyl radical, thiobarbituric acid reactive substances (TBARS), carbonyl concentration. An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profiles and therefore may play an important role in the antiobesity and hypolipidemic effects of ETJKB. |
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Authors:
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Cheol-Hwan Park; Soo-Jin Jeong; Hyo-Jeong Lee; Eun-Ok Lee; Hyunsu Bae; Min-Ho Lee; Sun-Hyung Kim; Hee-Jae Jung; Kyoo Seok Ahn; Sung-Hoon Kim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 24 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1700-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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College of Oriental Medicine, Kyung Hee University, 1 Hoegidong, Dongdaemungu, Seoul 130-701, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Animals Anti-Obesity Agents / pharmacology* Antioxidants / metabolism* Body Weight / drug effects* Catalase / metabolism Cholesterol / blood Glutathione Peroxidase / metabolism Hypolipidemic Agents / pharmacology* Leptin / analysis Lipid Peroxidation Lipoproteins, LDL / blood Liver / drug effects Male Medicine, Korean Traditional Mice Plant Extracts / pharmacology* Rats Rats, Sprague-Dawley Superoxide Dismutase / metabolism Thiobarbituric Acid Reactive Substances / analysis Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Antioxidants; 0/Hypolipidemic Agents; 0/Leptin; 0/Lipoproteins, LDL; 0/Plant Extracts; 0/Thiobarbituric Acid Reactive Substances; 0/Triglycerides; 57-88-5/Cholesterol; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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