| Traditional laboratory measures of cardiovascular risk in hereditary spherocytosis. | |
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MedLine Citation:
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PMID: 20589636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Individuals who have undergone splenectomy may be at an increased risk of arterial and venous thrombosis. We sought to determine if splenectomy affects surrogate laboratory measures of cardiovascular risk in persons with hereditary spherocytosis (HS). PROCEDURE: We conducted a prospective cross-sectional study of 21 children and 36 adults with HS. Fasting blood samples were collected for complete blood count and plasma lipid panel, homocysteine, lipoprotein (a), C-reactive protein, and fibrinogen. The variables were compared between the groups with and without prior splenectomy by Mann-Whitney tests. RESULTS: Subjects with prior splenectomy had higher hemoglobin, white blood cell and platelet counts and lower reticulocyte counts and total serum bilirubin concentrations (P < 0.001). Subjects not having had splenectomy had lower than normal levels of total and LDL-cholesterol (LDL-C). Total and LDL-C values were significantly higher, as were fibrinogen and homocysteine concentrations, in the post-splenectomy subjects than in individuals with intact spleen. CONCLUSION: Various lipid levels and other measures of cardiovascular risk are affected by splenectomy in persons with HS. Further investigations are indicated to more clearly define the balance of the potential benefits of hemolysis and anemia versus the deleterious effects of splenectomy in HS. |
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Authors:
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Shelley E Crary; Sarah Troendle; Naveed Ahmad; George R Buchanan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-27 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 684-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA. shelley.crary@utsouthwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bilirubin / blood Blood Cell Count C-Reactive Protein / analysis Cardiovascular Diseases / blood, etiology* Child Child, Preschool Cholesterol, LDL / blood Cross-Sectional Studies Female Humans Lipids / blood Male Middle Aged Prospective Studies Spherocytosis, Hereditary / blood* Splenectomy |
| Grant Support | |
ID/Acronym/Agency:
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5 KL2 RR024983-02/RR/NCRR NIH HHS; 5 UL1 RR024982-02/RR/NCRR NIH HHS; KL2 RR024983-02/RR/NCRR NIH HHS; UL1 RR024982-02/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Lipids; 635-65-4/Bilirubin; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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