| Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre. | |
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MedLine Citation:
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PMID: 21049180 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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METHOD: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1*0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level: Normal (N) - Hypocretin-1 higher than 110 pg/ml and Lower (L) Hypocretin-1 lower than 110 pg/ml. RESULTS: Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p = 0.0002). DISCUSSION: This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1*0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1*0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy. |
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Authors:
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Fernando Morgadinho Santos Coelho; Márcia Pradella-Hallinan; Mario Pedrazzoli; Carlos Augusto Senne Soares; Gustavo Bruniera Peres Fernandes; André Leite Gonçalves; Sergio Tufik; Lia Rita Azeredo Bittencourt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 68 ISSN: 1678-4227 ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 712-5 Citation Subset: IM |
Affiliation:
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Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil. fernandomorgadinho@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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