Document Detail


Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development.
MedLine Citation:
PMID:  22006424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.
METHODS: We studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.
RESULTS: Conventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.
CONCLUSION: Conventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.
Authors:
Elise Roze; Polly A Harris; Gareth Ball; Leire Zubiaurre Elorza; Rodrigo M Braga; Joanna M Allsop; Nazakat Merchant; Emma Porter; Tomoki Arichi; A David Edwards; Mary A Rutherford; Frances M Cowan; Serena J Counsell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-18
Journal Detail:
Title:  Neuroradiology     Volume:  54     ISSN:  1432-1920     ISO Abbreviation:  Neuroradiology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-09-20     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  507-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anisotropy
Brain Infarction / complications*
Brain Ischemia / complications*
Case-Control Studies
Diffusion Tensor Imaging / methods*
Female
Hemiplegia / etiology*,  physiopathology*
Humans
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Infant
Male
Motor Skills / physiology*
Neurologic Examination
Predictive Value of Tests
Pyramidal Tracts / injuries*
Stroke / complications*
Grant Support
ID/Acronym/Agency:
MC_U120081323//Medical Research Council; //Medical Research Council

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