Document Detail

Tract-based spatial statistics (TBSS): application to detecting white matter tract variation in mild hypoxic-ischemic neonates.
MedLine Citation:
PMID:  23365921     Owner:  NLM     Status:  MEDLINE    
The aim of this study is to employ tract-based spatial statistics (TBSS) to analyze the voxel-wise differences in DTI parameters between normal and mild hypoxic-ischemic (HI) neonatal brains. Forty-one full term neonates (24 normal controls and 17 with mild HI injury) and 31 preterm neonates (20 normal controls and 11 with mild HI injury) underwent T1 weighted imaging, T2 weighted imaging and diffusion tensor imaging (DTI) within 28 days after birth. The voxel differences of fractional anisotropy (FA), λ1, λ2, and λ3 values between mild HI group and control group were analyzed in preterm and full term neonates respectively. The significantly decreased FA with increased λ2, λ3 in corticospinal tract, genu of corpus callosum (GCC), external capsule (EC) and splenium of the corpus callosum (SCC) in mild HI neonates suggested deficits or delays in both myelination and premyelination. Such impaired corticospinal tract, in both preterm and term neonates, may directly lead to the subsequent poor motor performance. Impaired EC and SCC, the additional injured sites observed in full term neonates with mild HI injury, may be causally responsible for the dysfunction in coordination and integration. In conclusion, TBSS provides an objective, independent and sensitive method for DTI data analysis of neonatal white matter alterations after mild HI injury.
Jie Gao; Xianjun Li; Xin Hou; Abby Ding; Kevin C Chan; Qinli Sun; Ed X Wu; Jian Yang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-09-06     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-5     Citation Subset:  IM    
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MeSH Terms
Brain / pathology*
Case-Control Studies
Corpus Callosum / pathology
Diffusion Tensor Imaging / statistics & numerical data*
Hypoxia-Ischemia, Brain / diagnosis*,  pathology
Image Interpretation, Computer-Assisted / methods
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging / statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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