Document Detail

Tracking coronary calcification and atherosclerotic lesions in patients with stable angina pectoris undergoing nifedipine therapy.
MedLine Citation:
PMID:  16940720     Owner:  NLM     Status:  MEDLINE    
AIMS: The objective of the Coronary Calcification (CC) study was to determine in patients with chronic symptomatic coronary artery disease, if, in addition to standard therapy, nifedipine GITS, relative to placebo, would arrest or slow down the progression of calcium or the development of new atherosclerotic lesions in the coronary arteries. METHODS AND RESULTS: The CC study was part of the ACTION trial. Multi-slice computerized tomography was used to measure and track the progression of CC. Five hundred and eighteen patients were included in this study. The changes in calcium score from baseline every 24 months, over a period of between 4.5 and 6 years, were similar in the nifedipine and placebo treatment groups (p = 0.8). Compared to placebo, more patients in the nifedipine group (71 vs. 60%) were free of new calcified atherosclerotic lesions during follow-up(p = 0.095). CONCLUSION: Nifedipine GITS was not effective in slowing down the progression of calcium in advanced atherosclerotic plaques in patients with stable angina pectoris. Although statistically not significant, Nifedipine demonstrated a trend in slowing down the development of new atherosclerotic lesions.
Michael Motro; Bridget-Anne Kirwan; Sophie de Brouwer; Philip A Poole-Wilson; Joseph Shemesh;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-28
Journal Detail:
Title:  Cardiology     Volume:  107     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-05     Completed Date:  2007-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel.
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MeSH Terms
Angina Pectoris / drug therapy*
Atherosclerosis / drug therapy*,  pathology
Calcinosis / drug therapy*,  pathology
Calcium Channel Blockers / therapeutic use*
Coronary Vessels / pathology
Middle Aged
Nifedipine / therapeutic use*
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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