Document Detail

Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease.
MedLine Citation:
PMID:  21126914     Owner:  NLM     Status:  MEDLINE    
Since the isolation of HIV, multiple transmissions are thought to have occurred between man and other old-world primates. Assessment of samples from apes and human beings with African equatorial forest ancestry has traced the origin of HIV-1 to chimpanzees, and dated its most recent common ancestor to 1908. The evolution of HIV-1 has been rapid, which has resulted in a complex classification, worldwide spread, and intermixing of strains; at least 48 circulating recombinant forms are currently identified. In addition to posing a nearly insurmountable challenge for diagnosis, treatment, vaccine development, and prevention, this extreme and divergent evolution has led to differences in virulence between HIV-1 groups, subtypes, or both. Coincidental changes in human migration in the Congo river basin also affected spread of disease. Research over the past 25 years and advances in genomic sequencing methods, such as deep DNA sequencing, have greatly improved understanding and analysis of the thousands to millions of full infectious HIV-1 genomes.
Denis M Tebit; Eric J Arts
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-12-02
Journal Detail:
Title:  The Lancet. Infectious diseases     Volume:  11     ISSN:  1474-4457     ISO Abbreviation:  Lancet Infect Dis     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-01-24     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101130150     Medline TA:  Lancet Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-56     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Africa / epidemiology
Emigration and Immigration
Evolution, Molecular*
HIV Infections / drug therapy,  epidemiology*,  history*,  prevention & control
HIV-1 / classification,  genetics,  isolation & purification,  pathogenicity*
History, 20th Century
History, 21st Century
Primate Diseases / transmission*,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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