| Tracking serum lipid levels and the association of cholesterol concentrations, blood pressure and cigarette smoking with carotid artery intima-media thickness in young adults born small for gestational age. | |
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MedLine Citation:
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PMID: 20921815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Small birth size is associated with increased cardiovascular disease risk, but the mediating factors are poorly understood. METHODS AND RESULTS: Serum lipids, blood pressure (BP), carotid artery intima-media thickness (CA-IMT), and brachial artery flow-mediated dilatation (BA-FMD) were studied in 70 20-year-old subjects [35 sex- and age-matched pairs born small (SGA) and appropriate for gestational age (AGA)]. The SGA subjects had higher serum levels of low-density lipoprotein (LDL) cholesterol, total/high-density lipoprotein (HDL) and LDL/HDL cholesterol ratios, and lower HDL cholesterol levels than the AGA subjects (2.71 vs 2.37 mmol/L, P<0.05; 3.12 vs 2.80, P<0.01; 1.98 vs 1.61, P=0.002; 1.43 vs 1.56 mmol/L, P<0.05, respectively). In the SGA group, total and LDL cholesterol levels correlated inversely with adult height SD score (r=0.463, P=0.006 and r=0.413, P=0.015, respectively). CA-IMT or BA-FMD did not differ between the groups, but cigarette smoking, higher diastolic BP, and shorter birth length associated with higher CA-IMT in the whole study population. A clear tracking of cholesterol levels was found from 12 to 20 years. Conclusions: SGA subjects had more unfavorable lipid profiles than the controls, the shortest having the highest LDL cholesterol. Cigarette smoking, higher diastolic BP, and shorter birth length associated with higher CA-IMT in the whole study population. A clear tracking of cholesterol levels through adolescence enables early targeting of lifestyle counseling for reducing cardiovascular disease risk. |
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Authors:
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Maria Salonen; Sirpa Tenhola; Tomi Laitinen; Tiina Lyyra-Laitinen; Jarkko Romppanen; Jarmo Jääskeläinen; Raimo Voutilainen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-29 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2010-11-30 Revised Date: 2011-02-18 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 2419-25 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Blood Pressure* Body Size Carotid Arteries / ultrasonography* Carotid Artery Diseases / blood, epidemiology*, physiopathology, ultrasonography Case-Control Studies Child Cholesterol / blood Dyslipidemias / blood, epidemiology Female Finland / epidemiology Humans Hypertension / epidemiology, physiopathology Infant, Newborn Infant, Small for Gestational Age* Lipids / blood* Logistic Models Male Risk Assessment Risk Factors Smoking / epidemiology* Tunica Intima / ultrasonography* Tunica Media / ultrasonography* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 57-88-5/Cholesterol |
| Comments/Corrections | |
Comment In:
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Circ J. 2010 Nov;74(11):2299-300
[PMID:
20962427
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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