| Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease. | |
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MedLine Citation:
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PMID: 21451535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indicate that insulin plays an important role in maintaining the glomerular filtration barrier. Mima et al. report that glomeruli of diabetic and obese rats suffer from insulin resistance and altered insulin signaling. Protein kinase C inhibitors are able to overcome insulin resistance, offering new hopes for the treatment of the condition. |
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Authors:
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Gene-Yuan Chang; Ae Seo Deok Park; Katalin Susztak |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Kidney international Volume: 79 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-31 Completed Date: 2011-08-12 Revised Date: 2013-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 802-4 Citation Subset: IM |
Copyright Information:
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© 2011 International Society of Nephrology |
Affiliation:
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Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetic Nephropathies / drug therapy, etiology, physiopathology* Disease Models, Animal Humans Insulin / physiology* Insulin Resistance Kidney Glomerulus / physiopathology* Protein Kinase C / antagonists & inhibitors Rats Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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DK076077/DK/NIDDK NIH HHS; DK087635/DK/NIDDK NIH HHS; R01 DK076077-04/DK/NIDDK NIH HHS; R01 DK076077-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; EC 2.7.11.13/Protein Kinase C |
| Comments/Corrections | |
Comment On:
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Kidney Int. 2011 Apr;79(8):883-96
[PMID:
21228767
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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