Document Detail


Tracing the fate of dietary fatty acids: metabolic studies of postprandial lipaemia in human subjects.
MedLine Citation:
PMID:  21781361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most postprandial studies have investigated the response of a single meal, yet the ingestion of sequential meals is more typical in a Western society. The aim of this review is to explain how natural and stable isotope tracers of fatty acids have been used to investigate the metabolism of dietary fat after single and multiple meals, with a focus on in vivo measurements of adipose tissue metabolism. When stable isotope tracers are combined with arteriovenous difference measurements, very specific measurements of metabolic flux across tissues can be made. We have found that adipose tissue is a net importer of dietary fat for 5 h following a single test meal and for most of the day during a typical three-meal eating pattern. When dietary fat is cleared from plasma, some fatty acids 'spillover' into the plasma and contribute up to 50% of postprandial plasma NEFA concentrations. Therefore, plasma NEFA concentrations after a meal reflect the balance between intracellular and extracellular lipolysis in adipose tissue. This balance is altered after the acute ingestion of fructose. The enzyme lipoprotein lipase is a key modulator of fatty acid flux in adipose tissue and its rate of action is severely diminished in obese men. In conclusion, in vivo studies of human metabolism can quantify the way that adipose tissue fatty acid trafficking modulates plasma lipid concentrations. This has implications for the flux of fatty acids to tissues that are susceptible to ectopic fat deposition such as the liver and muscle.
Authors:
Barbara Fielding
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  70     ISSN:  1475-2719     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-25     Completed Date:  2012-01-25     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  342-50     Citation Subset:  IM    
Affiliation:
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK and Postgraduate Medical School, University of Surrey, Guildford, UK. barbara.fielding@ocdem.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Dietary Fats / metabolism*
Fatty Acids / blood,  metabolism*
Fatty Acids, Nonesterified / blood
Fructose / pharmacology
Humans
Hyperlipidemias / metabolism*
Isotopes
Lipid Metabolism*
Lipolysis
Lipoprotein Lipase / metabolism
Male
Obesity / metabolism
Postprandial Period
Staining and Labeling
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Isotopes; 30237-26-4/Fructose; EC 3.1.1.34/Lipoprotein Lipase

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