Document Detail


Tracheal mucous transport in experimental canine asthma.
MedLine Citation:
PMID:  1213976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tracheal mucous velocity (TMV) was measured in experimental canine asthma. All 10 sensitive dogs exposed to an aerosol of Ascaris suum extract showed a decrease in TMV to about one-third of base-line values within 45 min whereas only half of them (reactors) responded with bronchospasm as measured by a significant reduction in specific respiratory system conductance (SGrs). Mean TMV remained decreased at the end of the 2-h observation period when mean SGrs had returned to base-line values in the reactors. Neither TMV nor SGrs changed in nonsensitive animals who inhaled ragweed antigen. Aerosols of acetylcholine and histamine increased TMV thereby excluding these mediators as responsible for the impairment of mucous transport in asthma. Nebulization of A. suum antigen together with a selective antagonist of slow reacting substance of anaphylaxis (srs-a) produced a marked increase of TMV in all dogs regardless of whether or not bronchospasm was elicited. This suggests that the observed decrease in TMV may be related to the release of SRS-A during the immunologic reaction.
Authors:
A Wanner; S Zarzecki; J Hirsch; S Epstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology     Volume:  39     ISSN:  0021-8987     ISO Abbreviation:  J Appl Physiol     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-04-27     Completed Date:  1976-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376576     Medline TA:  J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  950-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens
Ascaris / immunology
Asthma / physiopathology*
Cilia*
Dogs
Lung Compliance
Mucus*
Trachea / physiopathology
Chemical
Reg. No./Substance:
0/Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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