| Tracheal intubating conditions and pharmacodynamics following cisatracurium in infants and children undergoing halothane and thiopental-fentanyl anesthesia. | |
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MedLine Citation:
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PMID: 17238881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aims of the present study were to determine the tracheal intubating conditions, onset time, duration of action, and hemodynamic responses following the administration of cisatracurium 0.15 mg x kg(-1) to infants and children. METHODS: One hundred and eighty-one infants and children aged 1 month to 12 years were randomized to two groups to receive anesthesia with nitrous oxide-oxygen-halothane (group H) or nitrous oxide-oxygen-thiopental-fentanyl (group TF). Intubation conditions were assessed 120 s after cisatracurium administration using a 4-part scale. Neuromuscular transmission was monitored by recording the evoked compound electromyogram of the adductor pollicis. RESULTS: The proportion of patients with excellent or good intubating conditions was similar in both groups (88 of 90, 98% in group H; 85 of 90, 94% in group TF). However, there was a significantly greater proportion of excellent intubating conditions in group H (79 of 90, 88%) compared with group TF (65 of 90, 72%) (P = 0.01) and recovery time was significantly longer in group H compared with group TF (P < 0.001). There was also a higher proportion of excellent intubating conditions in infants compared with older subjects (P = 0.02) and a shorter onset time (P < 0.001) and longer recovery time (P < 0.001) in younger compared with older patients. Changes in heart rate and arterial pressure were negligible 1 min following the cisatracurium administration. CONCLUSIONS: Cisatracurium 0.15 mg x kg(-1) produces acceptable intubating conditions at 120 s in the great majority of infants and children. Anesthesia background and age have significant effects on intubating conditions and duration of action of cisatracurium. |
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Authors:
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George H Meakin; Olli A Meretoja; Russell J Perkins; Ian Waite; Tomi Taivainen; Kari Wirtavuori; Anthony K Murphy; Leena Raiha |
Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 17 ISSN: 1155-5645 ISO Abbreviation: Paediatr Anaesth Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-22 Completed Date: 2007-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Royal Manchester Children's Hospital, Pendlebury, Manchester, UK. george.meakin@manchester.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Recovery Period Anesthesia, General / methods* Anesthetics, Combined / administration & dosage Anesthetics, Inhalation / administration & dosage Anesthetics, Intravenous / administration & dosage Atracurium / adverse effects, analogs & derivatives*, pharmacology Blood Pressure / drug effects Child Child, Preschool Electromyography / methods Female Fentanyl / administration & dosage* Halothane / administration & dosage* Heart Rate / drug effects Humans Infant Intubation, Intratracheal / methods* Male Neuromuscular Blocking Agents / adverse effects, pharmacology Nitrous Oxide / administration & dosage Oxygen / administration & dosage Thiopental / administration & dosage* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Combined; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Neuromuscular Blocking Agents; 0/cisatracurium; 10024-97-2/Nitrous Oxide; 151-67-7/Halothane; 437-38-7/Fentanyl; 64228-79-1/Atracurium; 76-75-5/Thiopental; 7782-44-7/Oxygen |
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