| Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice. | |
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MedLine Citation:
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PMID: 19043282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24 hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1beta level in BALF in the RPC group was significantly elevated at 24 hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24 hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12 hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF. |
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Authors:
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Syunji Yokota; Takayuki Seki; Yukiko Naito; Shigehiro Tachibana; Naoyuki Hirabayashi; Toshiaki Nakasaka; Naoki Ohara; Hiroyuki Kobayashi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 33 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 609-20 Citation Subset: IM |
Affiliation:
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First Laboratory of Toxicology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan. yokota.s@fdsc.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / cytology, immunology Cytokines / immunology Inhalation Exposure / adverse effects Kidney / drug effects, immunology Leukocyte Count Liver / drug effects, immunology Male Mice Mice, Inbred Strains Myocardium / enzymology, immunology, metabolism* Neutrophil Infiltration / drug effects*, immunology Neutrophils / cytology, drug effects*, immunology Oxidative Stress / drug effects*, immunology Particulate Matter / toxicity* Peroxidase / metabolism Pneumonia* / blood, chemically induced, immunology Trachea / drug effects* Vehicle Emissions / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Particulate Matter; 0/Vehicle Emissions; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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