| Tracheal Replacement with Fresh and Cryopreserved Aortic Allograft in Adult Dog. | |
| | |
MedLine Citation:
|
PMID: 21571308 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Many reports have described tracheal replacement using aortic allografts, with varying results and minimal understanding of the mechanism of tracheal regeneration. The present study attempted tracheal regeneration in adult dogs using fresh aortic allografts (FAA) and cryopreserved aortic allografts (CAA). MATERIALS AND METHODS: Twelve adult beagles underwent tracheal resection and were transplanted with FAA (n = 5) or CAA (n = 7). Animals were followed-up with serial radiography and magnetic resonance imaging, and were euthanized at predetermined times up to 16 mo post-surgery. RESULTS: There were no procedural deaths, but two animals died due to stent migration. Stent migration occurred in seven of the 12 animals. Evidence of regeneration of tracheal epithelium was observed in the surviving animals, with the transformation of squamous metaplasia to mucociliary epithelium being time-dependent. Islet of cartilage were observed in animals after 6 mo, but ring-like cartilage structures were absent, even after 16 mo. During autopsy, axial graft contractions up to 68% were observed. Serial radiographs show that most of the contraction occurred within 1 mo. The results of the MRI showed that the graft area was strongly enhanced for up to 2 mo, but was clearly reduced after 3 mo. CONCLUSIONS: Tracheal replacement in adult dogs using FAA or CAA is feasible. However, immaturity of the neotracheal cartilage did not allow the tissue to function as native tracheal tissue. Prolonged stenting should be considered in adult if the procedure is to be clinically contemplated. |
| | |
Authors:
|
Dae-Hyun Kim; Chi-Bong Choi; Wo-Jong Yang; Wook-Hun Chung; A-Jin Lee; Dai-Jung Chung; Soo-Yeol Lee; Sun-Hee Do; Hwi-Yool Kim |
Related Documents
:
|
23172678 - Cor-triatriatum: an unusual cause of elevated pulmonary capillary wedge pressure in a c... 23587108 - Open triple-branched stent graft applied to patient of acute type a aortic dissection w... 23455868 - Dabigatran etexilate: management in acute ischemic stroke. 23421858 - Clinical usefulness of portal venous stent in hepatobiliary pancreatic cancers. 16110368 - What are the skills that prepare vascular surgeons for carotid stenting? 16533698 - Coronary artery aneurysm: management and association with abdominal aortic aneurysm. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-19 |
Journal Detail:
|
Title: The Journal of surgical research Volume: - ISSN: 1095-8673 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-5-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Flow through a mechanical distraction enterogenesis device: a pilot test.
Next Document: Parathyroidectomy in the Elderly: Analysis of 7313 Patients.