Document Detail

Tracheal occlusion for fetal congenital diaphragmatic hernia: the US experience.
MedLine Citation:
PMID:  19559324     Owner:  NLM     Status:  MEDLINE    
Congenital diaphragmatic hernia (CDH) is characterized by a defect in the diaphragm that permits abdominal viscera to herniate into the chest. These herniated viscera are thought to compress the growing lung and cause lung parenchymal and vascular hypoplasia. The genetic defects that cause the diaphragmatic defect may also contribute primarily to lung hypoplasia. Postnatal reduction of the herniated abdominal viscera and correction of the diaphragmatic defect are easily achievable, but the lung hypoplasia persists, often leading to persistent fetal circulation and respiratory failure. This article reviews the experimental basis of fetal therapy for CDH and the US clinical experience with tracheal occlusion.
Eric Jelin; Hanmin Lee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  36     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-61, ix     Citation Subset:  IM    
Division of Pediatric Surgery, Department of Surgery, Fetal Treatment Center, University of California, San Francisco, CA 94143-0570, USA.
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MeSH Terms
Fetus / surgery*
Hernia, Diaphragmatic / congenital*,  diagnosis,  surgery
Prenatal Diagnosis / methods*
Surgical Procedures, Operative / methods*
Tracheal Stenosis / diagnosis,  etiology*,  surgery
United States

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