| Tracer kinetic analysis of signal time series from dynamic contrast-enhanced MR imaging. | |
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MedLine Citation:
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PMID: 17155868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rapid magnetic resonance imaging (MRI) makes it possible to detect the fast kinetics of tissue response after intravenous administration of a paramagnetic contrast medium (CM), reflecting the status of tissue microcirculation. In this paper, the basic physical and tracer kinetic principles of dynamic relaxivity and susceptibility contrast-enhanced MRI are reviewed. Quantitative analysis of data acquired is broken up into an MR-specific part, in which the signal variation observed is related to the CM concentration in the tissue, and an MR-independent part, in which the computed concentration time series are analyzed by tracer kinetic modeling to estimate well-defined physiological tissue parameters. The clinical application of dynamic MRI techniques is demonstrated by two representative studies. |
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Authors:
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Gunnar Brix; Robert Lucht; Jürgen Griebel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biomedizinische Technik. Biomedical engineering Volume: 51 ISSN: 0013-5585 ISO Abbreviation: Biomed Tech (Berl) Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-02-07 Revised Date: 2010-11-05 |
Medline Journal Info:
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Nlm Unique ID: 1262533 Medline TA: Biomed Tech (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 325-30 Citation Subset: IM |
Affiliation:
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Federal Office for Radiation Protection, Department of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany. gbrix@bfs.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Computer Simulation Contrast Media* Dye Dilution Technique* Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Kinetics Magnetic Resonance Imaging / methods* Models, Biological* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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