| Traceless liquid phase synthesis of piperazinediones. | |
| | |
MedLine Citation:
|
PMID: 12678708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Liquid phase combinatorial synthesis (LPCS) of piperazinediones by the use of soluble polymer support is explored to generate libraries. Proline anchored polyethylene glycol monomethyl ether (PEG) underwent dipeptide formation with different Fmoc-amino acids in the presence of dicyclohexyl carbodiimide (DCC). Deprotection of Fmoc accompanied with the cleavage from polymer support with cyclization of dipeptide to piperazinediones offers a facile and effective way to prepare diverse combinatorial libraries. Excellent yields and purities were achieved by simple wash and precipitation method. |
| | |
Authors:
|
Chung-Ming Sun; K M K Swamy; Mei-Jung Lin; Wen-Ben Yeh; Fred Y Chen; Wei-Hong Tseng |
Related Documents
:
|
9595328 - Comparison of community based smoke detector distribution methods in an urban community. 15030188 - Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction ch... 17386548 - Enhancement of the detection sensitivity for volatile organic compounds by using an ann... 15460258 - Multiple-detector responses or multiple-retention times: what is more informative for g... 15907618 - Simultaneous quantification of six major active saponins of panax notoginseng by high-p... 15664748 - Separation and characterization of synthetic impurities of triclabendazole by reversed-... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Combinatorial chemistry & high throughput screening Volume: 6 ISSN: 1386-2073 ISO Abbreviation: Comb. Chem. High Throughput Screen. Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-04-07 Completed Date: 2003-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9810948 Medline TA: Comb Chem High Throughput Screen Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 133-7 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan. cmsun@mail.ndhu.edu.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
chemistry Combinatorial Chemistry Techniques Cyclization Dicyclohexylcarbodiimide Dipeptides / chemical synthesis Fluorenes / chemistry Hydrogen-Ion Concentration* Indicators and Reagents Piperazines / chemical synthesis* Polyethylene Glycols |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Dipeptides; 0/Fluorenes; 0/Indicators and Reagents; 0/N(alpha)-fluorenylmethyloxycarbonylamino acids; 0/Piperazines; 0/Polyethylene Glycols; 538-75-0/Dicyclohexylcarbodiimide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Potential of peptides selected from random phage-displayed libraries to mimic conformational epitope...
Next Document: Tetraacyldiborates: selective and efficient acylation reagents suitable for multiple parallel synthe...