Document Detail


Traceless liquid phase synthesis of piperazinediones.
MedLine Citation:
PMID:  12678708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liquid phase combinatorial synthesis (LPCS) of piperazinediones by the use of soluble polymer support is explored to generate libraries. Proline anchored polyethylene glycol monomethyl ether (PEG) underwent dipeptide formation with different Fmoc-amino acids in the presence of dicyclohexyl carbodiimide (DCC). Deprotection of Fmoc accompanied with the cleavage from polymer support with cyclization of dipeptide to piperazinediones offers a facile and effective way to prepare diverse combinatorial libraries. Excellent yields and purities were achieved by simple wash and precipitation method.
Authors:
Chung-Ming Sun; K M K Swamy; Mei-Jung Lin; Wen-Ben Yeh; Fred Y Chen; Wei-Hong Tseng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Combinatorial chemistry & high throughput screening     Volume:  6     ISSN:  1386-2073     ISO Abbreviation:  Comb. Chem. High Throughput Screen.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-07     Completed Date:  2003-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9810948     Medline TA:  Comb Chem High Throughput Screen     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan. cmsun@mail.ndhu.edu.tw
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry
Combinatorial Chemistry Techniques
Cyclization
Dicyclohexylcarbodiimide
Dipeptides / chemical synthesis
Fluorenes / chemistry
Hydrogen-Ion Concentration*
Indicators and Reagents
Piperazines / chemical synthesis*
Polyethylene Glycols
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Dipeptides; 0/Fluorenes; 0/Indicators and Reagents; 0/N(alpha)-fluorenylmethyloxycarbonylamino acids; 0/Piperazines; 0/Polyethylene Glycols; 538-75-0/Dicyclohexylcarbodiimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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