Document Detail


Trace elements and oxidative stress in hypertensive disorders of pregnancy.
MedLine Citation:
PMID:  22878906     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Due to increased metabolic requests, pregnancy can be considered as metabolic stress, especially if associated with oxidative stress triggered by disbalance of pro/antioxidants. The aim of the study was to determine serum concentrations of the trace elements iron (Fe), zinc (Zn) and copper (Cu) important in growth regulation and pro/anti-oxidant homeostasis, in relation to the total serum oxidant capacity (TOC) and total serum antioxidant capacity (TAC) in pregnant women with preeclampsia (n = 30) or with gestational hypertension (n = 30) and in healthy pregnant women (n = 37) and non-pregnant women (n = 30) as control groups expecting common differences between all pregnant women and controls and between preeclampsia and the other pregnancies indicating specific disbalance of the oxidative stress and analyzed trace elements. METHODS: Serum Fe was determined by spectrophotometric method, Cu and Zn were determined by atomic absorption spectrometry, TOC was determined by Enzymatic ANTIOX-CAP assay and TAC by Peroxide-activity assay. RESULTS: Serum Cu and TOC were significantly higher while Zn was lower in all pregnant groups regardless of hypertensive disorders. Serum Fe and TAC concentrations were found to be significantly higher in pregnant women with preeclampsia compared to pregnant controls. CONCLUSION: Increase of TOC in all pregnant women our study points to latent oxidative stress in pregnancy. Fe might have a role in etiopathogenesis of preeclampsia while the increase of TAC in the very beginning of preeclampsia might represent a stressdefence mechanism of the body. It has still to be revealed whether significantly higher serum Fe levels are associated with preeclampsia as a cause or as a consequence of this disorder.
Authors:
Vanja Fenzl; Zlata Flegar-Meštrić; Sonja Perkov; Luka Andrišić; Franz Tatzber; Neven Zarković; Zeljko Duić
Related Documents :
1399336 - A methodology for simulating the impact of dna-probe services on the outcomes of pregna...
10400176 - Behaviour of finnish 3-year-old children. i: effects of sociodemographic factors, mothe...
9313186 - One day you're pregnant and one day you're not: pregnancy interruption for fetal anomal...
20809676 - Unintended pregnancy and prenatal care: a study from a maternity hospital in turkey.
18982836 - Selective serotonin reuptake inhibitor induced neonatal abstinence syndrome.
9883406 - Early cervical length, preterm prelabor and gestational age at delivery. is there a rel...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gynecology and Obstetrics, University Hospital "Merkur", Zajčeva 19, 10000, Zagreb, Croatia, vanja.radic@inet.hr.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of cerebrolysin administration on oxidative stress-induced apoptosis in lymphocytes from CAD...
Next Document:  Could maternal pre-pregnancy body mass index affect Apgar score?