Document Detail

Trace elements in nails as biomarkers in clinical research.
MedLine Citation:
PMID:  20813017     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The importance of trace elements in relation to human health has been increasingly recognized. Accurate and adequate quantification of trace elements are crucial in clinical research.
DESIGN: This review was to discuss the rationale of using nail trace elements as biomarkers in clinical studies.
RESULTS: For most trace elements, dietary instruments cannot appropriately capture the intakes because of the minimal amounts and wide variations in the same foods grown in different area as well as the nondietary exposures. Therefore, biomarkers may be essential in studying trace elements. Although there are notable differences among trace elements in the availability of biomarkers, increasing evidence supports that nails, particularly toenail concentrations of most trace elements, are useful biomarkers of exposure in which a single sample is assumed to represent long-term exposure.
CONCLUSIONS: Compared with other potential biomarkers of trace elements, nail measurement has certain advantages in clinical research.
Ka He
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-08-31
Journal Detail:
Title:  European journal of clinical investigation     Volume:  41     ISSN:  1365-2362     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-05-06     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM    
Copyright Information:
© 2010 The Author. European Journal of Clinical Investigation © 2010 Stichting European Society for Clinical Investigation Journal Foundation.
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MeSH Terms
Biological Markers / analysis*
Biomedical Research / methods
Nails / chemistry*
Predictive Value of Tests
Trace Elements / analysis*
Grant Support
R01 HL081572/HL/NHLBI NIH HHS; R01 HL081572-01A1/HL/NHLBI NIH HHS; R01 HL081572-02/HL/NHLBI NIH HHS; R01 HL081572-02S1/HL/NHLBI NIH HHS; R01 HL081572-03/HL/NHLBI NIH HHS; R01HL081572/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Trace Elements

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