Document Detail

Trace elements, heavy metals and other biochemical parameters in malignant glioma patients.
MedLine Citation:
PMID:  21545211     Owner:  NLM     Status:  MEDLINE    
AIM: We aimed to assess relevance of mineral, trace element and heavy metal levels in patients with malignant gliomas.
METHODS: In this study, erythrocyte catalase (CAT), and carbonic anhydrase (CA), serum copper (Cu.), zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn), and magnesium (Mg) levels were measured in 22 healthy humans and 22 malignant glioma patients. Metal concentrations were assessed by atomic adsorption spectrophotometry, while biochemical methods were used for CAT and CA.
RESULTS: The Cd, Fe, Mg, Mn, Pb and Zn levels were significantly elevated in the patients as a whole compared to controls(P<0.05), while Cu was decreased and Co demonstrated no change. Although mean CAT activity were significantly lowered, CA exhibited significant increase.
CONCLUSIONS: The results of the current study indicate that antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with malignant glioma. CAT and CA seem to play particular roles in the pathophysiology of this disease.
Mehmet Arslan; Halit Demir; Harun Arslan; A Samet Gokalp; Canan Demir
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  12     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-06     Completed Date:  2011-08-18     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  IM    
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MeSH Terms
Brain / enzymology
Brain Neoplasms / blood*,  enzymology
Carbonic Anhydrases / blood*
Catalase / blood*
Erythrocytes / enzymology*
Glioma / blood*,  enzymology
Metals, Heavy / blood*
Middle Aged
Spectrophotometry, Atomic
Trace Elements / blood*
Tumor Markers, Biological / blood
Reg. No./Substance:
0/Metals, Heavy; 0/Trace Elements; 0/Tumor Markers, Biological; EC; EC Anhydrases

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