Document Detail


Trabeculated (noncompacted) and compact myocardium in adults: the multi-ethnic study of atherosclerosis.
MedLine Citation:
PMID:  22499849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A high degree of noncompacted (trabeculated) myocardium in relationship to compact myocardium (trabeculated to compact myocardium [T/M] ratio >2.3) has been associated with a diagnosis of left ventricular noncompaction (LVNC). The purpose of this study was to determine the normal range of the T/M ratio in a large population-based study and to examine the relationship to demographic and clinical parameters.
METHODS AND RESULTS: The thickness of trabeculation and the compact myocardium were measured in 8 left ventricular regions on long axis cardiac MR steady-state free precession cine images in 1000 participants (551 women; 68.1±8.9 years) of the Multi-Ethnic Study of Atherosclerosis cohort. Of 323 participants without cardiac disease or hypertension and with all regions evaluable, 140 (43%) had a T/M ratio >2.3 in at least 1 region; in 20 of 323 (6%), T/M >2.3 was present in >2 regions. A multivariable linear regression model revealed no association of age, sex, ethnicity, height, and weight with maximum T/M ratio in participants without cardiac disease or hypertension (P>0.05). In the entire cohort (n=1000), left ventricular ejection fraction (β=-0.02/%; P=0.015), left ventricular end-diastolic volume (β=0.01/mL; P<0.0001), and left ventricular end-systolic volume (β=0.01/mL; P<0.001) were associated with maximum T/M ratio in adjusted models, whereas there was no association with hypertension or myocardial infarction (P>0.05). At the apical level, T/M ratios were significantly lower when obtained on short- compared with long-axis images (P=0.017).
CONCLUSIONS: A ratio of T/M of >2.3 is common in a large population-based cohort. These results suggest re-evaluation of the current cardiac MR criteria for left ventricular noncompaction may be necessary.
Authors:
Nadine Kawel; Marcelo Nacif; Andrew E Arai; Antoinette S Gomes; W Gregory Hundley; W Craig Johnson; Martin R Prince; R Brandon Stacey; João A C Lima; David A Bluemke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-12
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  5     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-17     Completed Date:  2012-07-23     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-66     Citation Subset:  IM    
Affiliation:
Radiology and Imaging Sciences and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Atherosclerosis / diagnosis*,  ethnology*
Cohort Studies
Contrast Media / diagnostic use
Ethnic Groups / statistics & numerical data*
Female
Gadolinium DTPA / diagnostic use
Humans
Image Enhancement / methods
Isolated Noncompaction of the Ventricular Myocardium / diagnosis*
Magnetic Resonance Imaging, Cine / methods
Male
Middle Aged
Myocardium / pathology*
Observer Variation
Population Surveillance
Sensitivity and Specificity
Ventricular Function, Left
Grant Support
ID/Acronym/Agency:
N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS; ZIA CL090019-02/CL/CLC NIH HHS; ZIA EB000072-02/EB/NIBIB NIH HHS; ZID HL006140-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA
Comments/Corrections

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