| Trabeculated (noncompacted) and compact myocardium in adults: the multi-ethnic study of atherosclerosis. | |
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MedLine Citation:
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PMID: 22499849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A high degree of noncompacted (trabeculated) myocardium in relationship to compact myocardium (trabeculated to compact myocardium [T/M] ratio >2.3) has been associated with a diagnosis of left ventricular noncompaction (LVNC). The purpose of this study was to determine the normal range of the T/M ratio in a large population-based study and to examine the relationship to demographic and clinical parameters. METHODS AND RESULTS: The thickness of trabeculation and the compact myocardium were measured in 8 left ventricular regions on long axis cardiac MR steady-state free precession cine images in 1000 participants (551 women; 68.1±8.9 years) of the Multi-Ethnic Study of Atherosclerosis cohort. Of 323 participants without cardiac disease or hypertension and with all regions evaluable, 140 (43%) had a T/M ratio >2.3 in at least 1 region; in 20 of 323 (6%), T/M >2.3 was present in >2 regions. A multivariable linear regression model revealed no association of age, sex, ethnicity, height, and weight with maximum T/M ratio in participants without cardiac disease or hypertension (P>0.05). In the entire cohort (n=1000), left ventricular ejection fraction (β=-0.02/%; P=0.015), left ventricular end-diastolic volume (β=0.01/mL; P<0.0001), and left ventricular end-systolic volume (β=0.01/mL; P<0.001) were associated with maximum T/M ratio in adjusted models, whereas there was no association with hypertension or myocardial infarction (P>0.05). At the apical level, T/M ratios were significantly lower when obtained on short- compared with long-axis images (P=0.017). CONCLUSIONS: A ratio of T/M of >2.3 is common in a large population-based cohort. These results suggest re-evaluation of the current cardiac MR criteria for left ventricular noncompaction may be necessary. |
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Authors:
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Nadine Kawel; Marcelo Nacif; Andrew E Arai; Antoinette S Gomes; W Gregory Hundley; W Craig Johnson; Martin R Prince; R Brandon Stacey; João A C Lima; David A Bluemke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-04-12 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: 5 ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-17 Completed Date: 2012-07-23 Revised Date: 2013-05-03 |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 357-66 Citation Subset: IM |
Affiliation:
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Radiology and Imaging Sciences and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Atherosclerosis / diagnosis*, ethnology* Cohort Studies Contrast Media / diagnostic use Ethnic Groups / statistics & numerical data* Female Gadolinium DTPA / diagnostic use Humans Image Enhancement / methods Isolated Noncompaction of the Ventricular Myocardium / diagnosis* Magnetic Resonance Imaging, Cine / methods Male Middle Aged Myocardium / pathology* Observer Variation Population Surveillance Sensitivity and Specificity Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS; ZIA CL090019-02/CL/CLC NIH HHS; ZIA EB000072-02/EB/NIBIB NIH HHS; ZID HL006140-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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