| Trabecular bone mineral density in primary hyperparathyroidism: relationship to clinical presentation and biomarkers of skeletal turnover. | |
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MedLine Citation:
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PMID: 8453327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was carried out in order to investigate the entity of trabecular bone involvement in 62 patients with primary hyperparathyroidism (PHPT). Bone mineral density (BMD) was measured in all patients at the ultradistal radius (UDR) of the non-dominant arm by a dual photon densitometer and also at the lumbar spine (L) in 40 of the patients by means of quantitative dual energy radiography. Mean Z score values of UDR-BMD (-2.4 +/- 0.4) and L-BMD (-3.5 +/- 0.2) in patients with the skeletal variety of the disease (n = 6) were significantly reduced in respect to values of both asymptomatic (n = 31) and kidney stone patients (n = 25). As far as the comparison between the two sites of trabecular bone mass measurement in each hyperparathyroid subgroup of patients was concerned, a significant difference (P < 0.05) was found in patients with skeletal manifestations of the disease. Either serum total alkaline phosphatase activity, or osteocalcin and the 24-h hydroxyproline/creatinine ratio were significantly inversely related to the entity of bone mass evaluated at these two sites. Z score changes following surgery in 14 patients showed a positive trend in 13 of them at L compared to 7 out of 14 at UDR (P < 0.036 by chi square analysis). There was a very good inverse correlation between basal Z score values and the changes following surgery at the L (r = -0.851; P < 0.001) but not at the UDR. Our results demonstrate firstly that, in PHPT skeletal sites with almost similar composition of trabecular bone are differently involved in patients with more severe skeletal damage and that different skeletal sites may be divergently affected by the cessation of parathyroid gland hyperfunction. |
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Authors:
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S Minisola; R Rosso; E Romagnoli; M T Pacitti; L Scarnecchia; V Carnevale; G Mazzuoli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bone and mineral Volume: 20 ISSN: 0169-6009 ISO Abbreviation: Bone Miner Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-04-22 Completed Date: 1993-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610542 Medline TA: Bone Miner Country: IRELAND |
Other Details:
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Languages: eng Pagination: 113-23 Citation Subset: IM |
Affiliation:
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Istituto di II Clinica Medica, Università degli Studi di Roma La Sapienza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Alkaline Phosphatase / blood Biological Markers / analysis Bone Density* Calcium / urine Creatinine / urine Female Humans Hydroxyproline / urine Hyperparathyroidism / metabolism, physiopathology* Kidney Calculi / physiopathology Male Middle Aged Osteocalcin / blood Phosphorus / urine |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 104982-03-8/Osteocalcin; 51-35-4/Hydroxyproline; 60-27-5/Creatinine; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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