Document Detail


T(peak)T(end) interval in long QT syndrome.
MedLine Citation:
PMID:  18822425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.
Authors:
Jorgen K Kanters; Christian Haarmark; Esben Vedel-Larsen; Mads P Andersen; Claus Graff; Johannes J Struijk; Poul Erik Bloch Thomsen; Michael Christiansen; Henrik K Jensen; Egon Toft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-25
Journal Detail:
Title:  Journal of electrocardiology     Volume:  41     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-01-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-8     Citation Subset:  IM    
Affiliation:
Danish National Research Foundation Center of Arrhythmias (DARC), Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Comorbidity
Denmark / epidemiology
Diagnosis, Computer-Assisted / methods*
Electrocardiography / methods*,  statistics & numerical data*
Female
Humans
Incidence
Long QT Syndrome / diagnosis*,  epidemiology*
Male
Reproducibility of Results
Risk Assessment / methods*
Risk Factors
Sensitivity and Specificity
Syncope / diagnosis*,  epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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