| Tpeak-Tend interval as an index of global dispersion of ventricular repolarization: evaluations using monophasic action potential mapping of the epi- and endocardium in swine. | |
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MedLine Citation:
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PMID: 16374554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ECG interval from the peak to the end of the T wave (Tpeak-Tend) has been used as an index of transmural dispersion of ventricular repolarization (DVR). The correlation between the Tpeak-Tend interval and the global DVR, however, has not been well-evaluated. METHODS: Monophasic action potentials (MAPs) were recorded from 51+/-10 epicardial and 64 +/- 9 endocardial sites in the left ventricles of 10 pigs, and from 41+/-4 epicardial and 53+/-2 endocardial sites in the right ventricles of 2 of the 10 pigs using the CARTO mapping system. The end of repolarization times over the epi- and endocardium were measured, and the end of repolarization dispersions over the epicardium (DVR-epi), over the endocardium (DVR-endo) and over both (DVR-total) were calculated. The QTpeak, QTend and Tpeak-Tend intervals as well as the QTpeak and QTend dispersions were obtained from the simultaneously recorded 12-lead ECG. RESULTS: The maximal Tpeak-Tend intervals (57+/-7 ms) were consistent with the DVR-total (58+/-11 ms, p>0.05), and significantly correlated with the DVR-total (r=0.64, p<0.05). However, the mean Tpeak-Tend intervals (44+/-5 ms), and Tpeak-Tend intervals from lead II (41+/-6 ms) and V5 (43+/-5 ms) were all significantly smaller than and poorly correlated with the DVR-total, as were the QTpeak and QTend dispersions (15+/-2 ms vs. 21+/-4 ms). CONCLUSION: The maximal Tpeak-Tend interval may be used as a noninvasive estimate for the global DVR, but not the QTpeak and QTend dispersions, nor the mean Tpeak-Tend interval and that from a single lead. |
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Authors:
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Yunlong Xia; Yanchun Liang; Ole Kongstad; Magnus Holm; Bertil Olsson; Shiwen Yuan |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing Volume: 14 ISSN: 1383-875X ISO Abbreviation: J Interv Card Electrophysiol Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-12-23 Completed Date: 2006-10-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9708966 Medline TA: J Interv Card Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital, Lund, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Animals Body Surface Potential Mapping / methods* Diagnosis, Computer-Assisted / methods* Endocardium / physiology* Health Status Indicators Heart Conduction System / physiology* Pericardium / physiology* Swine Ventricular Function* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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