Document Detail


Tp53 codon-72 polymorphisms identify different radiation sensitivities to g2-chromosome breakage in human lymphoblast cells.
MedLine Citation:
PMID:  21038427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both the G2 chromosomal radiosensitivity assay and allelic differences in TP53 codon-72 have been associated with cancer predisposition. The relationship between the two endpoints was determined in 56 human EBV-transformed lymphoblastoid cell lines. Although there were overlapping distributions of sensitivity for the different genotypes, cell lines that were homozygous for the proline coding allele were more likely to be resistant to chromatid break formation than those containing two arginine coding alleles, whereas cell lines expressing both the proline and arginine codon were either resistant like proline-proline lines or sensitive like arginine-arginine lines. The results support an important role of the TP53 codon-72 polymorphism in modifying G2-chromosome radiosensitivity. Distinguishing the effect of TP53 codon-72 variations from other modifiers of G2-chromosome radiosensitivity might aid in identifying new markers of cancer risk.
Authors:
Jeffrey L Schwartz; David Plotnik; Jana Slovic; Tiffany Li; Maximillian Racelis; H Joachim Deeg; Debra L Friedman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental and molecular mutagenesis     Volume:  52     ISSN:  1098-2280     ISO Abbreviation:  Environ. Mol. Mutagen.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-12     Completed Date:  2011-02-08     Revised Date:  2014-08-26    
Medline Journal Info:
Nlm Unique ID:  8800109     Medline TA:  Environ Mol Mutagen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Cesium Radioisotopes
Chromosome Breakage / radiation effects*
Codon / genetics*
Genes, p53 / genetics*
Genetic Predisposition to Disease / genetics
Humans
Lymphocytes / metabolism*,  radiation effects*
Polymorphism, Genetic / genetics*
Radiation Tolerance / genetics*
Grant Support
ID/Acronym/Agency:
CA102542/CA/NCI NIH HHS; CA15704/CA/NCI NIH HHS; CA18029/CA/NCI NIH HHS; HL36444/HL/NHLBI NIH HHS; R01 CA102542/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cesium Radioisotopes; 0/Codon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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