| Toxoplasma-induced autophagy: a window into nutritional futile cycles in mammalian cells? | |
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MedLine Citation:
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PMID: 19305153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation and function of autophagy in response to metabolic signals is not yet well understood. A recent study from our laboratory indicates that an intracellular parasite, Toxoplasma gondii, derives nutritive benefit from the upregulation of host cell autophagy. We discuss this and related findings suggesting that autophagy in infected cells functions as part of a metabolic futile cycle. The hypothesis is presented that endogenous autophagy-based futile cycles may operate in normal mammalian cells, providing a substrate for manipulation by pathogens. |
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Authors:
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Amos Orlofsky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-04-09 |
Journal Detail:
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Title: Autophagy Volume: 5 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 404-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. orlofsky@aecom.yu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy / physiology* Host-Parasite Interactions* Signal Transduction / physiology Substrate Cycling / physiology* Toxoplasma / metabolism*, pathogenicity* |
| Grant Support | |
ID/Acronym/Agency:
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AI-51519/AI/NIAID NIH HHS; AI-55358/AI/NIAID NIH HHS; R01 AI055358-01A1/AI/NIAID NIH HHS; R01 AI055358-02/AI/NIAID NIH HHS; R01 AI055358-03/AI/NIAID NIH HHS; R01 AI055358-04/AI/NIAID NIH HHS; R01 AI055358-05/AI/NIAID NIH HHS |
| Comments/Corrections | |
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