Document Detail


Toxoplasma gondii pneumonia in liver transplantation: survival after a severe case of reactivation.
MedLine Citation:
PMID:  12220246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxoplasmosis is an infrequent infection in solid organ transplantation, except in heart transplantation, where the grafting of a positive organ in a negative recipient transmits the infection in a high percentage of cases, in the absence of prophylaxis. We report a case of pneumonia by Toxoplasma gondii in a woman who received a liver transplant and had pre-transplant positive serology. Diagnosis was made by cytologic examination of bronchoalveolar lavage fluid, where the parasite was observed with hematoxylin-eosin and Giemsa staining. That finding was confirmed by direct immunofluorescence and positive polymerase chain reaction. The patient had a favorable outcome, although she had not initially received first-choice drugs. This was a case of severe illness secondary to reactivation of Toxoplasma infection, diagnosed pre-mortem and with a favorable outcome. Duration of treatment and need for secondary prophylaxis in these patients are discussed in the literature. Although infrequent, toxoplasmosis must be considered among the differential diagnoses of pulmonary infiltrates in solid organ transplantation.
Authors:
Laura A Barcán; M L Dallurzo; L O Clara; A Valledor; S Macías; E Zorkin; S Gerona; B Livellara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transplant infectious disease : an official journal of the Transplantation Society     Volume:  4     ISSN:  1398-2273     ISO Abbreviation:  Transpl Infect Dis     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2002-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100883688     Medline TA:  Transpl Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Affiliation:
Infectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Gascón 450, Capital Federal, Buenos Aires, Argentina. lbarcan@intramed.net.ar
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / therapeutic use
Female
Humans
Liver Transplantation / adverse effects*
Middle Aged
Pneumonia / drug therapy,  parasitology*
Recurrence
Survival
Toxoplasma / isolation & purification,  physiology*
Toxoplasmosis / drug therapy,  parasitology*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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