Document Detail

Toxoplasma gondii: inhibition of the intracellular growth by human lactoferrin.
MedLine Citation:
PMID:  17419186     Owner:  NLM     Status:  MEDLINE    
In the present paper we focused on the potential role of human lactoferrin for the intracellular replication rate of T. gondii BK tachyzoites following our earlier observation that Toxoplasma gondii was able to bind human lactoferrin but not serum transferrin. The study was performed in vitro on human CaCo-2 epithelial cells and mouse L929 fibroblasts. We found that the multiplication of the parasite was inhibited by lactoferrin in both cell lines used. However, the direct cytotoxic effect on the parasite and the host cells was not observed. The intracellular growth of T. gondii was not affected when tachyzoites or host cells were only pre-coated with human lactoferrin. The results suggest that lactoferrin does not influence parasites penetration into host cells but could trigger unknown antiparasitic mechanisms in the infected cells.
Katarzyna Dzitko; Bozena Dziadek; Jarosław Dziadek; Henryka Długońska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists     Volume:  56     ISSN:  1733-1331     ISO Abbreviation:  Pol. J. Microbiol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-10     Completed Date:  2007-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101229003     Medline TA:  Pol J Microbiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
Department of Immunoparasitology, Institute of Microbiology and Immunology, University of Lódź, Lódź, Poland.
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MeSH Terms
Cell Line
Host-Parasite Interactions / physiology*
Lactoferrin / physiology*
Toxoplasma / growth & development,  pathogenicity,  physiology*
Reg. No./Substance:

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