Document Detail


A Toxoplasma gondii Superantigen: Biological effects and implications for the host-parasite interaction.
MedLine Citation:
PMID:  15275175     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Superantigens exert their biological effects by activating large families of T cells, based on expression of the variable beta chain of the T-cell receptor. As a result, the reactive cells proliferate, secrete high levels of inflammatory cytokines, and ultimately die or become anergic to further stimulation. It is now becoming clear that the intracellular protozoan Toxoplasma gondii has many of these same superantigenic properties. As discussed here by Eric Denkers, this activity may play a key role in the induction of cell-mediated immunity to the parasite, and may prove to be responsible for much of the pathology associated with the clinical manifestations of toxoplasmosis.
Authors:
E Y Denkers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Parasitology today (Personal ed.)     Volume:  12     ISSN:  0169-4758     ISO Abbreviation:  Parasitol. Today (Regul. Ed.)     Publication Date:  1996 Sep 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2005-04-12     Revised Date:  2005-04-15    
Medline Journal Info:
Nlm Unique ID:  8605563     Medline TA:  Parasitol Today     Country:  England    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  -    
Affiliation:
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA. eyd1@cornell.edu
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Comment In:
Parasitol Today. 1997 Feb;13(2):82; author reply 83   [PMID:  15275129 ]

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