Document Detail


Toxoplasma gondii: congenital transmission in a hamster model.
MedLine Citation:
PMID:  19217907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (n=168). Of 32 females with a chronic toxoplasma infection, 3 transmitted Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis.
Authors:
A Freyre; C G Fialho; L E Bigatti; F A P Araujo; J D Falcón; J Mendez; M González
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Publication Detail:
Type:  Journal Article     Date:  2009-02-13
Journal Detail:
Title:  Experimental parasitology     Volume:  122     ISSN:  1090-2449     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
Affiliation:
Laboratorio de Toxoplasmosis, Departamento de Parasitología, Alberto Lasplaces 1550, Montevideo 11600, Uruguay. freyrealvaro@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Biological Assay
Cats
Cricetinae
Disease Models, Animal
Female
Infectious Disease Transmission, Vertical*
Mesocricetus
Mice
Milk / parasitology
Pregnancy
Pregnancy Complications, Parasitic / parasitology*
Pregnancy Tests
Toxoplasmosis, Animal / congenital*,  transmission
Toxoplasmosis, Congenital / transmission*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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