| Toxoplasma Co-opts Host Cells It Does Not Invade. | |
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MedLine Citation:
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PMID: 22910631 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Like many intracellular microbes, the protozoan parasite Toxoplasma gondii injects effector proteins into cells it invades. One group of these effector proteins is injected from specialized organelles called the rhoptries, which have previously been described to discharge their contents only during successful invasion of a host cell. In this report, using several reporter systems, we show that in vitro the parasite injects rhoptry proteins into cells it does not productively invade and that the rhoptry effector proteins can manipulate the uninfected cell in a similar manner to infected cells. In addition, as one of the reporter systems uses a rhoptry:Cre recombinase fusion protein, we show that in Cre-reporter mice infected with an encysting Toxoplasma-Cre strain, uninfected-injected cells, which could be derived from aborted invasion or cell-intrinsic killing after invasion, are actually more common than infected-injected cells, especially in the mouse brain, where Toxoplasma encysts and persists. This phenomenon has important implications for how Toxoplasma globally affects its host and opens a new avenue for how other intracellular microbes may similarly manipulate the host environment at large. |
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Authors:
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Anita A Koshy; Hans K Dietrich; David A Christian; Jason H Melehani; Anjali J Shastri; Christopher A Hunter; John C Boothroyd |
Publication Detail:
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Type: Journal Article Date: 2012-07-26 |
Journal Detail:
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Title: PLoS pathogens Volume: 8 ISSN: 1553-7374 ISO Abbreviation: PLoS Pathog. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-08-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101238921 Medline TA: PLoS Pathog Country: United States |
Other Details:
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Languages: eng Pagination: e1002825 Citation Subset: IM |
Affiliation:
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Department of Medicine (Infectious Disease), Stanford University School of Medicine, Stanford, California, United States of America. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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