| Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest. | |
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MedLine Citation:
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PMID: 12970556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antibiotic resistance, virulence, and other plasmids in bacteria use toxin-antitoxin gene pairs to ensure their persistence during host replication. The toxin-antitoxin system eliminates plasmid-free cells that emerge as a result of segregation or replication defects and contributes to intra- and interspecies plasmid dissemination. Chromosomal homologs of toxin-antitoxin genes are widely distributed in pathogenic and other bacteria and induce reversible cell cycle arrest or programmed cell death in response to starvation or other adverse conditions. The dissection of the interaction of the toxins with intracellular targets and the elucidation of the tertiary structures of toxin-antitoxin complexes have provided exciting insights into toxin-antitoxin behavior. |
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Authors:
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Finbarr Hayes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 301 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-12 Completed Date: 2003-09-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1496-9 Citation Subset: IM |
Affiliation:
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Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK. finbarr.hayes@umist.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Bacteria / genetics, pathogenicity Bacterial Physiological Phenomena* Bacterial Proteins / genetics, metabolism* Cell Cycle* Chromosomes, Bacterial DNA, Bacterial / metabolism Plasmids* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/DNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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