| Toxin on a stick: Modular CDI toxin delivery systems play roles in bacterial competition. | |
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MedLine Citation:
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PMID: 21705856 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Contact-dependent growth inhibition (CDI) is the first contact-dependent competition system identified in bacteria. CDI is mediated by the CdiA/CdiB two-partner secretion system, and the BamA outer membrane protein serves as the CDI receptor on target cells. A small immunity protein, CdiI, is required to protect inhibitor cells from their own CDI system. Recent results from our group show that CDI systems are present in a number of important gram-negative plant and animal pathogens. The C-terminal region of CdiA (CdiA-CT) is polymorphic and contains growth inhibitory activity. The CdiA-CT from uropathogenic Esherichia coli 536 is a tRNase whereas a CdiA-CT from Dickeya dadantii 3937 has DNase activity. Accordingly, these bacteria contain distinct CdiI proteins, which specifically bind and inactivate cognate CdiA-CT. Remarkably, CdiA-CTs are modular: one CdiA "stick" can deliver different CdiA-CT toxins. We discuss these findings as well as results showing that CDI plays an important role in intra-strain bacterial competition in the natural world. A detailed mechanistic understanding of CDI could facilitate development of probiotics and antimicrobials that target specific pathogens. |
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Authors:
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Stephanie K Aoki; Stephen J Poole; Christopher S Hayes; David A Low |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-01 |
Journal Detail:
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Title: Virulence Volume: 2 ISSN: 2150-5608 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Molecular Cellular and Developmental Biology; University of California at Santa Barbara; Santa Barbara, CA USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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