Document Detail

Toxin entry: how bacterial proteins get into mammalian cells.
MedLine Citation:
PMID:  11207543     Owner:  NLM     Status:  MEDLINE    
Certain bacteria secrete protein toxins that catalytically modify and disrupt essential processes in mammalian cells, often leading to cell death. As the substrates modified by these toxins are located in the mammalian cell cytosol, a catalytically active toxin polypeptide must reach this compartment in order to act. The toxins bind to receptors on the surface of susceptible cells and enter them by endocytic uptake. Endocytosed toxins initially accumulate in endosomes, where some of these proteins take advantage of the acidic environment within these organelles to form, or contribute to the formation of, protein-conducting channels through which the catalytic polypeptide is able to translocate into the cytosol. Other toxins are unable to respond to low pH in this way and must undergo intracellular vesicular transport to reach a compartment where pre-existing protein-conducting channels occur and can be exploited for membrane translocation--the endoplasmic reticulum. In this way, cell entry by this second group of toxins demonstrates that the secretory pathway of mammalian cells is completely reversible.
J M Lord; D C Smith; L M Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cellular microbiology     Volume:  1     ISSN:  1462-5814     ISO Abbreviation:  Cell. Microbiol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883691     Medline TA:  Cell Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Department of Biological Sciences, University of Warwick, Coventry, UK.
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MeSH Terms
Bacterial Toxins / metabolism*
Biological Transport
Cell Membrane / metabolism*
Endoplasmic Reticulum / metabolism
Endosomes / metabolism*
Hydrogen-Ion Concentration
Intracellular Membranes / metabolism
Protein Synthesis Inhibitors / metabolism*
Receptors, Cell Surface / metabolism*
Reg. No./Substance:
0/Bacterial Toxins; 0/Protein Synthesis Inhibitors; 0/Receptors, Cell Surface

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