Document Detail

Toxicology of the retina: advances in understanding the defence mechanisms and pathogenesis of drug- and light-induced retinopathy.
MedLine Citation:
PMID:  18352876     Owner:  NLM     Status:  MEDLINE    
The neurosensory retina is a highly specialized sense organ that is subjected to constant exposure of systemic toxins, oxidative stress and focused light rays. Important advances have been made in recent decades in unravelling a myriad of defence mechanisms against such insults and consequently in improving the understanding of the principles underlying various drug- and light-induced disease processes. To defend against circulating toxins, the retina possesses a specialized blood-retinal barrier (BRB) that tightly regulates the transport of substances across the functional boundaries of the retina at the retinal capillaries and the retinal pigmented epithelium. An endogenous cytochrome p450 system is strategically located within the retina to neutralize agents that can diffuse through the BRB. The biooxidation effect of light is prevented by a wide array of unique antioxidant mechanisms in the retina. Nonetheless, pathological processes may evolve when these different lines of defence are overwhelmed by various xenobiotics, environmental agents such as cigarette smoke and excessive light exposure, particularly of short wavelength high frequency blue light and ultraviolet light. Latest research using transgenic models has revealed novel apoptotic pathways implicated in acute phototoxicity, in particular blue light damage, and provides important clues for further understanding the risks of high-frequency light exposure to human retinopathy. This review article summarizes the basic scientific principles of these different defence mechanisms and discuss the implications in pathophysiology and treatment.
Timothy L Siu; John W Morley; Minas T Coroneo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  36     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-04-03     Revised Date:  2009-02-10    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  176-85     Citation Subset:  IM    
School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
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MeSH Terms
Apoptosis / drug effects,  radiation effects
Blood-Retinal Barrier / physiology
Light / adverse effects*
Oxidative Stress / physiology
Retina / drug effects*,  radiation effects*
Retinal Diseases / etiology*,  physiopathology
Risk Factors
Xenobiotics / adverse effects*,  pharmacokinetics
Reg. No./Substance:
Comment In:
Clin Experiment Ophthalmol. 2008 Aug;36(6):583-4; author reply 584   [PMID:  18954326 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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