| Toxicology of alkylmercury compounds. | |
| | |
MedLine Citation:
|
PMID: 20877814 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail. |
| | |
Authors:
|
Michael Aschner; Natalia Onishchenko; Sandra Ceccatelli |
Related Documents
:
|
19740524 - Bioaccessibility of mercury from traditional northern country foods measured using an i... 22606204 - The prevalence of aflatoxinogenic aspergillus parasiticus in jordan. 11032134 - Human exposure to mercury due to small scale gold mining in northern tanzania. 20436784 - Rapid, efficient growth reduces mercury concentrations in stream-dwelling atlantic salmon. 15270494 - Use of carvacrol and cymene to control growth and viability of listeria monocytogenes c... 11198434 - Dietary strategies to counteract the effects of mycotoxins: a review. |
Publication Detail:
|
Type: Journal Article Date: 2010-01-30 |
Journal Detail:
|
Title: Metal ions in life sciences Volume: 7 ISSN: 1559-0836 ISO Abbreviation: Met Ions Life Sci Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101513478 Medline TA: Met Ions Life Sci Country: England |
Other Details:
|
Languages: eng Pagination: 403-34 Citation Subset: IM |
Affiliation:
|
Vanderbilt University School of Medicine, Department of Pediatrics, Pharmacology, and the Kennedy Center for Research on Human Development, Nashville, TN 37232, USA michael.aschner@vanderbilt.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Organomercurials. Their formation and pathways in the environment.
Next Document: Environmental Bioindication, Biomonitoring, and Bioremediation of Organometal(loid)s.