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Toxicology of alkylmercury compounds.
MedLine Citation:
PMID:  20877814     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.
Authors:
Michael Aschner; Natalia Onishchenko; Sandra Ceccatelli
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Publication Detail:
Type:  Journal Article     Date:  2010-01-30
Journal Detail:
Title:  Metal ions in life sciences     Volume:  7     ISSN:  1559-0836     ISO Abbreviation:  Met Ions Life Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101513478     Medline TA:  Met Ions Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-34     Citation Subset:  IM    
Affiliation:
Vanderbilt University School of Medicine, Department of Pediatrics, Pharmacology, and the Kennedy Center for Research on Human Development, Nashville, TN 37232, USA michael.aschner@vanderbilt.edu.
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